Biology:Insulysin
From HandWiki
Insulysin (EC 3.4.24.56) (Also called insulinase, insulin-degrading enzyme, insulin protease, insulin proteinase, insulin-degrading neutral proteinase, insulin-specific protease, insulin-glucagon protease, metalloinsulinase, IDE) is an enzyme.[1][2][3][4][5] This enzyme catalyses the degradation reaction of insulin, glucagon and other polypeptides.
This cytosolic enzyme is present in mammals and in many arthropods such as the fly Drosophila melanogaster.
See also
References
- ↑ "Insulin degradation: mechanisms, products, and significance". Endocrine Reviews 9 (3): 319–45. August 1988. doi:10.1210/edrv-9-3-319. PMID 3061785.
- ↑ "Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes". Molecular Endocrinology 4 (8): 1125–35. August 1990. doi:10.1210/mend-4-8-1125. PMID 2293021.
- ↑ "Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin". The Journal of Biological Chemistry 265 (5): 2984–7. February 1990. PMID 1689296.
- ↑ "Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme". Molecular Endocrinology 4 (10): 1580–91. October 1990. doi:10.1210/mend-4-10-1580. PMID 2126597.
- ↑ "Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III". The Journal of Biological Chemistry 267 (4): 2414–20. February 1992. PMID 1733942.
http://www.jneurosci.org/content/20/23/8745.full
External links
- Insulysin at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
