Biology:N-methylhydantoinase (ATP-hydrolysing)
N-methylhydantoinase (ATP-hydrolyzing) | |||||||||
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Identifiers | |||||||||
EC number | 3.5.2.14 | ||||||||
CAS number | 100785-00-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an N-methylhydantoinase (ATP-hydrolysing) (EC 3.5.2.14) is an enzyme that catalyzes the chemical reaction[1]
- ATP + N-methylimidazolidine-2,4-dione + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + N-carbamoylsarcosine
The 3 substrates of this enzyme are ATP, N-methylimidazolidine-2,4-dione, and H2O, whereas its 3 products are ADP, phosphate, and N-carbamoylsarcosine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing). Other names in common use include N-methylhydantoin amidohydrolase, methylhydantoin amidase, N-methylhydantoin hydrolase, and N-methylhydantoinase. This enzyme participates in arginine, creatinine, and proline metabolism.
References
- ↑ Nucleoside triphosphate-dependent 1-methylhydantoinase, a process for obtaining it and the use - United States Patent 4816393. Inventors: Siedel Joachim, Deeg Rolf, Roder Albert, Ziegenhorn Joachim, Mollering Hans, Gauhl Helmgard. Assignee: Boehringer Mannheim. Application Date: 1985-02-25. Publication Date: 1989-03-28.
- "Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis". Biochem. Biophys. Res. Commun. 142 (3): 1006–12. 1987. doi:10.1016/0006-291X(87)91514-2. PMID 3827889.
![]() | Original source: https://en.wikipedia.org/wiki/N-methylhydantoinase (ATP-hydrolysing).
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