Biology:Neurocalcin
| neurocalcin delta | |
|---|---|
 | |
| Identifiers | |
| Symbol | NCALD |
| NCBI gene | 83988 |
| HGNC | 7655 |
| OMIM | 606722 |
| RefSeq | NM_001040628 |
| UniProt | P61601 |
| Other data | |
| Locus | Chr. 8 q22-q23 |
Neurocalcin delta is a neuronal calcium-binding protein which in humans is encoded by the NCALD gene. Neurocalcin belongs to the neuronal calcium sensor (NCS) family of proteins.[1][2] It expressed in mammalian brains. It possesses a Ca2+/myristoyl switch
The subclass of neurocalcins are brain-specific proteins that fit into the EF-hand superfamily of calcium binding proteins. The NCS family were defined by the photoreceptor cell-specific protein, recoverin. Neurocalcin was purified from the bovine brain by using calcium-dependent drug affinity chromatography. The amino acid sequence showed that neurocalcin has three functional calcium binding sites. It is expressed in the central nervous system, retina, and adrenal gland. With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin.
Neurocalcin delta an isoform of Neurocalcin is known to regulate adult neurogenesis.[3]
References
- ↑ "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience 8 (3): 182–193. March 2007. doi:10.1038/nrn2093. PMID 17311005.
- ↑ "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends in Neurosciences 27 (4): 203–209. 2004. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
- ↑ "Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological". Frontiers in Molecular Neuroscience 12. 2019. doi:10.3389/fnmol.2019.00019. PMID 30853885.
Further reading
- "Neurocalcin: a novel calcium-binding protein from bovine brain". The Journal of Biological Chemistry 267 (27): 19596–19599. September 1992. doi:10.1016/S0021-9258(18)41816-9. PMID 1527077.
- "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neuroscience Research 16 (2): 73–77. February 1993. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172.
- "Calcium and membrane binding properties of bovine neurocalcin delta expressed in Escherichia coli". The Journal of Biological Chemistry 270 (7): 3179–3185. February 1995. doi:10.1016/S0021-9258(18)82908-8. PMID 7852401.
External links
- Neurocalcin at the US National Library of Medicine Medical Subject Headings (MeSH)
- NCS proteins
- [1] Protein Database Page
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