Biology:Sialidase-2

Short description: Protein-coding gene in the species Homo sapiens

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.^[1]^[2]^[3]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.^[3]

References

↑ "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. Jun 1999. doi:10.1006/geno.1999.5749. PMID 10191093.
↑ "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. Jan 2004. doi:10.1074/jbc.M308381200. PMID 14613940.
↑ ^3.0 ^3.1 "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4759.

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