Biology:Transpoviron
From HandWiki
A transpoviron is a plasmid-like genetic element found in the genomes of giant DNA viruses.[1][2] They are linear DNA elements of approximately 7 kilobases that encompass six to eight protein encoding genes. Two of these genes are homologous to virophage genes. Transpovirons encode a superfamily 1 helicase, which encompasses an inactivated family B DNA polymerase domain.[3] Homologs of this unique polymerase-helicase fusion protein are widespread in Polinton-Like Viruses (PLV).[4] Based on the phylogenetic analysis of the helicase domain the discoverers of PLVs concluded that transpovirons evolved from PLV via the loss of several genes including those encoding the morphogenetic module proteins.[3]
References
- ↑ Desnues, C; La Scola, B; Yutin, N; Fournous, G; Robert, C; Azza, S; Jardot, P; Monteil, S et al. (2012). "Provirophages and transpovirons as the diverse mobilome of giant viruses". Proc Natl Acad Sci USA 109 (44): 18078–83. doi:10.1073/pnas.1208835109. PMID 23071316. Bibcode: 2012PNAS..10918078D.
- ↑ Yutin, N; Raoult, D; Koonin, EV (2013). "Virophages, polintons, and transpovirons: a complex evolutionary network of diverse selfish genetic elements with different reproduction strategies". Virol J 10 (1): 158. doi:10.1186/1743-422x-10-158. PMID 23701946.
- ↑ 3.0 3.1 Mart Krupovic, Natalya Yutin, Eugene V. Koonin (2016). "Fusion of a superfamily 1 helicase and an inactivated DNA polymerase is a signature of common evolutionary history of Polintons, polinton-like viruses, Tlr1 transposons and transpovirons". Virus Evolution 2 (1): vew019. doi:10.1093/ve/vew019. PMID 28694999.
- ↑ Yutin, N; Shevchenko, S; Kapitonov, V; Krupovic, M; Koonin, EV (2015). "A novel group of diverse Polinton-like viruses discovered by metagenome analysis.". BMC Biology 13: 95. doi:10.1186/s12915-015-0207-4. PMID 26560305.
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