Biology:UTP—hexose-1-phosphate uridylyltransferase
UTP:galactose-1-phosphate uridylyltransferase | |||||||||
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UTP—galactose-1-phosphate uridylyltransferase homodimer, E.Coli | |||||||||
Identifiers | |||||||||
EC number | 2.7.7.10 | ||||||||
CAS number | 9016-11-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an UTP—hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) is an enzyme that catalyzes the chemical reaction
- UTP + alpha-D-galactose 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + UDP-galactose
Thus, the two substrates of this enzyme are UTP and alpha-D-galactose 1-phosphate, whereas its two products are diphosphate and UDP-galactose.
Enzyme family
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.
Structural studies
(As of 2007), 3 structures have been solved for this class of enzymes, with PDB accession codes 1GUP, 1GUQ, and 1HXP.
References
- ISSELBACHER KJ (1958). "A mammalian uridinediphosphate galactose pyrophosphorylase". J. Biol. Chem. 232 (1): 429–44. PMID 13549431.
- KALCKAR HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta 12 (1–2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.
- "Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum". J. Biochem. (Tokyo) 86 (4): 923–8. October 1979. doi:10.1093/oxfordjournals.jbchem.a132624. PMID 500588.
- "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica". Mol. Biochem. Parasitol. 7 (2): 173–82. 1983. doi:10.1016/0166-6851(83)90043-9. PMID 6304512.
Original source: https://en.wikipedia.org/wiki/UTP—hexose-1-phosphate uridylyltransferase.
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