Chemistry:Acacetin
From HandWiki
Acacetin is a 4′-O-methylated flavone of the parent compound apigenin, found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana), Betula pendula (silver birch),[1] and in the fern Asplenium normale.[2]
In plant synthesis the enzyme apigenin 4′-O-methyltransferase uses S-adenosyl methionine and 5,7,4′-trihydroxyflavone (apigenin) to produce S-adenosylhomocysteine and 4′-methoxy-5,7-dihydroxyflavone (acacetin).[3]
It shows moderate aromatase inhibition.[4]
See also
- Genkwanin (methoxylated apigenin)
- Thevetiaflavone (methoxylated apigenin)
References
- ↑ Valkama, E; Salminen, J-P; Koricheva, J; Pihlaja, K (2004). "Changes in leaf trichomes and epicuticular flavonoids during leaf development in three birch taxa". Annals of Botany 94 (2): 233–242. doi:10.1093/aob/mch131. PMID 15238348.
- ↑ UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). "Flavonoid distribution in asplenioid ferns". Pertanika 14 (3): 297–300.
- ↑ "The para-O-methylation of apigenin to acacetin by cell-free extracts of Robinia pseudoacacia L". Z. Naturforsch. C: Biosci. 36 (11–12): 916–920. 1981. doi:10.1515/znc-1981-11-1202.
- ↑ Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (December 2008). "Anti-aromatase activity of the constituents from damiana (Turnera diffusa)". Journal of Ethnopharmacology 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180.
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