Chemistry:Fosravuconazole
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| Trade names | Nailin |
| Other names | BMS-379224; BFE-1224; E-1224 |
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| Formula | C23H20F2N5O5PS |
| Molar mass | 547.47 g·mol−1 |
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Fosravuconazole (trade name Nailin) is a triazole antifungal agent.[1][2] In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail.[3] It is a prodrug that is converted into ravuconazole.[1]
Drugs for Neglected Diseases Initiative (DNDi) and the Japanese pharmaceutical company Eisai found that fosravuconazole works as a treatment for mycetoma, a serious condition.[1][4][5] The Phase II clinical trial found that oral fosravuconazole was safe, patient-friendly, and effective in treating eumycetoma.[6][7] Eumycetoma mainly affects young adults in poorer, rural areas; the standard treatment is itraconazole, which is much more expensive at about US$2,000 for a year than fosravuconazole and unaffordable, and not available in all endemic countries.[7]
References
- ↑ 1.0 1.1 1.2 "Potential of Ravuconazole and its Prodrugs as the New OralTherapeutics for Onychomycosis". Medical Mycology Journal 57 (4): E93–E110. 2016. doi:10.3314/mmj.16-00006. PMID 27904057.
- ↑ "Fosravuconazole - Seren Pharmaceuticals". Adis Insight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800018102.
- ↑ "Oral Antifungal Agent Nailin Capsules 100 mg Approved in Japan" (Press release). Eisai. January 19, 2018.
- ↑ "Fosravuconazole". Drugs for Neglected Diseases Initiative. 23 November 2023. https://www.dndi.org/diseases-projects/portfolio/fosravuconazole/.
- ↑ "Drugs for Neglected Diseases initiative and Eisai Co., Ltd. to Test Drug Candidate for Eumycetoma" (Press release). Eisai Co., Ltd. 10 September 2015.
- ↑ "World's first clinical trial for devastating fungal disease mycetoma shows efficacy of new, promising treatment" (Press release). Drugs for Neglected Diseases initiative (DNDi). 23 November 2023.
- ↑ 7.0 7.1 Johnson, Sarah (23 November 2023). "Cheap over-the-counter nail drug found to work on crippling flesh-eating disease". The Guardian. https://www.theguardian.com/global-development/2023/nov/23/fungal-nail-drug-fosravuconazole-breakthrough-treating-neglected-flesheating-disease-mycetoma. "The head of mycetoma at the DNDi labelled the discovery 'momentous', and said 'We were all very excited, it’s going to be a gamechanger'."
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