Medicine:Cataract

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Short description: Clouding of the lens inside the eye, causing poor vision
Cataract
Cataract in human eye.png
Magnified view of a cataract seen on examination with a slit lamp
SpecialtyOphthalmology, Optometry
SymptomsFaded colors, blurry vision, halos around light, trouble with bright lights, trouble seeing at night[1]
ComplicationsFalling, depression, blindness[2][3]
Usual onsetGradual[1]
CausesAging, trauma, radiation exposure, following eye surgery, genetic[1][4][5]
Risk factorsDiabetes, smoking tobacco, prolonged exposure to sunlight, alcohol[1]
Diagnostic methodEye examination[1]
PreventionSunglasses, proper diet, not smoking[1]
TreatmentGlasses, cataract surgery[1]
Frequency60 million (2015)[6]

A cataract is a cloudy area in the lens of the eye that leads to a decrease in vision of the eye.[1][7] Cataracts often develop slowly and can affect one or both eyes.[1] Symptoms may include faded colours, blurry or double vision, halos around light, trouble with bright lights, and difficulty seeing at night.[1] This may result in trouble driving, reading, or recognizing faces.[8] Poor vision caused by cataracts may also result in an increased risk of falling and depression.[2] Cataracts cause 51% of all cases of blindness and 33% of visual impairment worldwide.[3][9]

Cataracts are most commonly due to aging but may also occur due to trauma or radiation exposure, be present from birth, or occur following eye surgery for other problems.[1][4] Risk factors include diabetes, longstanding use of corticosteroid medication, smoking tobacco, prolonged exposure to sunlight, and alcohol.[1] The underlying mechanism involves accumulation of clumps of protein or yellow-brown pigment in the lens that reduces transmission of light to the retina at the back of the eye.[1] Diagnosis is by an eye examination.[1]

Wearing sunglasses and a wide brimmed hat, eating leafy vegetables and fruits, and avoiding smoking may reduce the risk of developing cataracts, or slow down the process.[1][10] Early on the symptoms may be improved with glasses.[1] If this does not help, surgery to remove the cloudy lens and replace it with an artificial lens is the only effective treatment.[1] Cataract surgery is not readily available in many countries, and surgery is needed only if the cataracts are causing problems and generally results in an improved quality of life.[1][11][4][12]

About 20 million people worldwide are blind due to cataracts.[4] It is the cause of approximately 5% of blindness in the United States and nearly 60% of blindness in parts of Africa and South America.[12] Blindness from cataracts occurs in about 10 to 40 per 100,000 children in the developing world, and 1 to 4 per 100,000 children in the developed world.[7] Cataracts become more common with age.[1] In the United States, cataracts occur in 68% of those over the age of 80 years.[13] Additionally they are more common in women, and less common in Hispanic and Black people.[13]

Signs and symptoms

An example of normal vision versus vision with cataracts.
Bilateral cataracts in an infant due to congenital rubella syndrome

Signs and symptoms vary depending on the type of cataract, though considerable overlap occurs. People with nuclear sclerotic or brunescent cataracts often notice a reduction of vision. Nuclear cataracts typically cause greater impairment of distance vision than of near vision. Those with posterior subcapsular cataracts usually complain of glare as their major symptom.[14]

The severity of cataract formation, assuming no other eye disease is present, is judged primarily by a visual acuity test. Other symptoms include frequent changes of glasses and colored halos due to hydration of lens.[citation needed]

Congenital cataracts can result in amblyopia if not treated in a timely manner.[15]

Causes

Age

Age is the most common cause of cataracts.[1][4] Lens proteins denature and degrade over time, and this process is accelerated by diseases such as diabetes mellitus and hypertension. Environmental factors, including toxins, radiation, and ultraviolet light have cumulative effects which are worsened by the loss of protective and restorative mechanisms due to alterations in gene expression and chemical processes within the eye.[16]

Oxidative stress associated with lipid peroxidation is an important pathogenic mechanism in cataract formation.[17][18] Senile cataracts are associated with a decrease in antioxidant capacity in the lens.[17] An increase in oxidative stress in the lens or a decrease in the ability to remove reactive oxygen species can lead to the lens becoming more opaque.[17]

Trauma

Post traumatic rosette cataract of a 60-year-old male

Blunt trauma causes swelling, thickening, and whitening of the lens fibers. While the swelling normally resolves with time, the white color may remain. In severe blunt trauma, or in injuries that penetrate the eye, the capsule in which the lens sits can be damaged. This damage allows fluid from other parts of the eye to rapidly enter the lens leading to swelling and then whitening, obstructing light from reaching the retina at the back of the eye. Cataracts may develop in 0.7 to 8.0% of cases following electrical injuries.[19] Blunt trauma can also result in star- (stellate) or petal-shaped cataracts.[20]

Radiation

Cataracts can arise as an effect of exposure to various types of radiation. X-rays, one form of ionizing radiation, may damage the DNA of lens cells.[21] Ultraviolet light, specifically UVB, has also been shown to cause cataracts, and some evidence indicates sunglasses worn at an early age can slow its development in later life.[22] Microwaves, a type of nonionizing radiation, may cause harm by denaturing protective enzymes (e.g., glutathione peroxidase), by oxidizing protein thiol groups (causing protein aggregation), or by damaging lens cells via thermoelastic expansion.[21] The protein coagulation caused by electric and heat injuries whitens the lens.[16] This same process is what makes the clear albumen of an egg become white and opaque during cooking.[citation needed]

Genetics

Christmas tree cataract (diffuse illumination)

The genetic component is strong in the development of cataracts,[23] most commonly through mechanisms that protect and maintain the lens. The presence of cataracts in childhood or early life can occasionally be due to a particular syndrome. Examples of chromosome abnormalities associated with cataracts include 1q21.1 deletion syndrome, cri-du-chat syndrome, Down syndrome, Patau's syndrome, trisomy 18 (Edward's syndrome), and Turner's syndrome, and in the case of neurofibromatosis type 2, juvenile cataract on one or both sides may be noted. Examples of single-gene disorder include Alport's syndrome, Conradi's syndrome, cerebrotendineous xanthomatosis, myotonic dystrophy, and oculocerebrorenal syndrome or Lowe syndrome.[citation needed]

Skin diseases

The skin and the lens have the same embryological origin and so can be affected by similar diseases.[24] Those with atopic dermatitis and eczema occasionally develop shield ulcer cataracts. Ichthyosis is an autosomal recessive disorder associated with cuneiform cataracts and nuclear sclerosis. Basal-cell nevus and pemphigus have similar associations.[citation needed]

Smoking and alcohol

Cigarette smoking has been shown to increase the risk of age-related cataract and nuclear cataract.[25][26] Evidence is conflicting over the effect of alcohol. Some surveys have shown a link, but others which followed people over longer terms have not.[27]

Inadequate vitamin C

Low vitamin C intake and serum levels have been associated with greater cataract rates.[28] However, use of supplements of vitamin C has not demonstrated benefit.[29]

Medications

Some medications, such as systemic, topical, or inhaled corticosteroids, may increase the risk of cataract development.[30][31] Corticosteroids most commonly cause posterior subcapsular cataracts.[31] People with schizophrenia often have risk factors for lens opacities (such as diabetes, hypertension, and poor nutrition). Second-generation antipsychotic medications are unlikely to contribute to cataract formation.[32] Miotics[33] and triparanol may increase the risk.[34]

Post-operative

Nearly every person who undergoes a vitrectomy—without ever having had cataract surgery—will experience progression of nuclear sclerosis after the operation.[35] This may be because the native vitreous humor is different from the solutions used to replace the vitreous (vitreous substitutes), such as BSS Plus.[36] This may also be because the native vitreous humour contains ascorbic acid which helps neutralize oxidative damage to the lens and because conventional vitreous substitutes do not contain ascorbic acid.[37][38] Accordingly, for phakic patients requiring a vitrectomy it is becoming increasingly common for ophthalmologists to offer the vitrectomy combined with prophylactic cataract surgery to prevent cataract formation.[39]

Hyperbaric oxygen therapy

Hyperbaric oxygen therapy (HBOT) is the administration of 100% oxygen at pressures greater than one-atmosphere absolute pressure (1 ATA) for a therapeutic purpose. HBOT can have several side effects, including the long-term development of cataracts. This is rare and generally associated with multiple HBOT exposures over a long period. As it does not usually become symptomatic during HBOT, it may often go unrecognised and is probably under-reported. Evidence is emerging that lifetime dosage of oxygen may be a precipitating factor in the development of age-related cataracts. Nuclear cataracts have been hypothesized to be the end stage of the far better known phenomenon of hyperbaric myopic shift.[40]

Other diseases

Diagnosis

Classification

Cross-sectional view, showing the position of the human lens

File:Fetal cataract.ogv

Cataracts may be partial or complete, stationary or progressive, hard or soft. Histologically, the main types of age-related cataracts are nuclear sclerosis, cortical, and posterior subcapsular.[41]

Nuclear sclerosis is the most common type of cataract, and involves the central or 'nuclear' part of the lens. This eventually becomes hard, or 'sclerotic', due to condensation on the lens nucleus and the deposition of brown pigment within the lens. In its advanced stages, it is called a brunescent cataract. In early stages, an increase in sclerosis may cause an increase in refractive index of the lens.[42] This causes a myopic shift (lenticular shift) that decreases hyperopia and enables presbyopic patients to see at near without reading glasses. This is only temporary and is called second sight.[citation needed]

Cortical cataracts are due to the lens cortex (outer layer) becoming opaque. They occur when changes in the fluid contained in the periphery of the lens causes fissuring. When these cataracts are viewed through an ophthalmoscope, or other magnification system, the appearance is similar to white spokes of a wheel. Symptoms often include problems with glare and light scatter at night.[42]

Posterior subcapsular cataracts are cloudy at the back of the lens adjacent to the capsule (or bag) in which the lens sits. Because light becomes more focused toward the back of the lens, they can cause disproportionate symptoms for their size.[citation needed]

An immature cataract has some transparent protein, but with a mature cataract, all the lens protein is opaque. In a hypermature or Morgagnian cataract, the lens proteins have become liquid. Congenital cataract, which may be detected in adulthood, has a different classification and includes lamellar, polar, and sutural cataracts.[43][44]

Cataracts can be classified by using the lens opacities classification system LOCS III. In this system, cataracts are classified based on type as nuclear, cortical, or posterior. The cataracts are further classified based on severity on a scale from 1 to 5. The LOCS III system is highly reproducible.[45]

Different types of cataracts
  • ppc

    Posterior polar cataract of an 8-year-old boy in left eye

  • ns

    Nuclear sclerosis cataract of a 70-year-old male

  • cc

    Cortical cataract of a 60-year-old male

  • cc

    Retroillumination of cortical cataract

  • psc

    Posterior subcapsular cataract of a 16-year-old girl with type 1 diabetes

  • ic

    Intumescent cataract of a 55-year-old male

  • asc

    Anterior subcapsular cataract having back shadow

  • psc

    Posterior subcapsular cataract by retroillumination

  • ns & ppc

    Nuclear sclerosis and posterior polar cataract of a 60-year-old female

  • dc

    Dense white mature cataract of a 60-year-old male

  • dc

    Cortical cataract of a melanoderm male

Prevention

Risk factors such as UVB exposure and smoking can be addressed. Although no means of preventing cataracts has been scientifically proven, wearing sunglasses that block ultraviolet light may slow their development.[46][47] While adequate intake of vitamins A, C, and E may protect against the risk of cataracts, clinical trials have shown no benefit from supplements,[29] although the evidence is mixed, but weakly positive, for a potential protective effect of the carotenoids, lutein and zeaxanthin.[48][49][50]

Treatment

Surgical

Main page: Physics:Cataract surgery
Cataract surgery, using a temporal-approach phacoemulsification probe (in right hand) and "chopper" (in left hand) being done under operating microscope at a navy medical center
Slit lamp photo of posterior capsular opacification visible a few months after implantation of intraocular lens, seen on retroillumination

The appropriateness of surgery depends on a person's particular functional and visual needs and other risk factors.[51] Cataract removal can be performed at any stage and no longer requires ripening of the lens.[clarification needed] Surgery is usually "outpatient" and usually performed using local anesthesia. About 9 of 10 patients can achieve a corrected vision of 20/40 or better after surgery.[42]

Several recent evaluations found that cataract surgery can meet expectations only when significant functional impairment due to cataracts exists before surgery. Visual function estimates such as VF-14 have been found to give more realistic estimates than visual acuity testing alone.[42][52] In some developed countries, a trend to overuse cataract surgery has been noted, which may lead to disappointing results.[53]

Phacoemulsification is the most widely used cataract surgery in the developed world.[54][55] This procedure uses ultrasonic energy to emulsify the cataract lens. Phacoemulsification typically comprises six steps:[citation needed]

  • Anaesthetic – The eye is numbed with either a subtenon injection around the eye (see: retrobulbar block) or topical anesthetic eye drops. The former also provides paralysis of the eye muscles.
  • Corneal incision – Two cuts are made at the margin of the clear cornea to allow insertion of instruments into the eye.
  • Capsulorhexis – A needle or small pair of forceps is used to create a circular hole in the capsule in which the lens sits.
  • Phacoemulsification – A handheld ultrasonic probe is used to break up and emulsify the lens into liquid using the energy of ultrasound waves. The resulting 'emulsion' is sucked away.
  • Irrigation and aspiration – The cortex, which is the soft outer layer of the cataract, is aspirated or sucked away. Fluid removed is continually replaced with a saline solution to prevent collapse of the structure of the anterior chamber (the front part of the eye).
  • Lens insertion – A plastic, foldable lens is inserted into the capsular bag that formerly contained the natural lens. Some surgeons also inject an antibiotic into the eye to reduce the risk of infection. The final step is to inject salt water into the corneal wounds to cause the area to swell and seal the incision.

A Cochrane review found little to no difference in visual acuity as a function of the size of incisions made for phacoemulsification in the range from ≤ 1.5 mm to 3.0 mm.[56] Extracapsular cataract extraction (ECCE) consists of removing the lens manually, but leaving the majority of the capsule intact.[57] The lens is expressed through a 10- to 12-mm incision which is closed with sutures at the end of surgery. ECCE is less frequently performed than phacoemulsification, but can be useful when dealing with very hard cataracts or other situations where emulsification is problematic. Manual small incision cataract surgery (MSICS) has evolved from ECCE. In MSICS, the lens is removed through a self-sealing scleral tunnel wound in the sclera which, ideally, is watertight and does not require suturing. Although "small", the incision is still markedly larger than the portal in phacoemulsification. This surgery is increasingly popular in the developing world where access to phacoemulsification is still limited.[citation needed]

Intracapsular cataract extraction (ICCE) is rarely performed.[58] The lens and surrounding capsule are removed in one piece through a large incision while pressure is applied to the vitreous membrane.[clarification needed] The surgery has a high rate of complications.[clarification needed][citation needed]

Prognosis

Postoperative care

Slit lamp photo of anterior capsular opacification visible a few months after implantation of intraocular lens, magnified view
A South African woman experiences newfound eyesight after a patch was removed after surgery to remove an eye cataract.

The postoperative recovery period (after removing the cataract) is usually short. The patient is usually ambulatory on the day of surgery, but is advised to move cautiously and avoid straining or heavy lifting for about a month. The eye is usually patched on the day of surgery and use of an eye shield at night is often suggested for several days after surgery.[51]

In all types of surgery, the cataractous lens is removed and replaced with an artificial lens, known as an intraocular lens, which stays in the eye permanently. Intraocular lenses are usually monofocal, correcting for either distance or near vision. Multifocal lenses may be implanted to improve near and distance vision simultaneously, but these lenses may increase the chance of unsatisfactory vision.[16]

Complications

Serious complications of cataract surgery include retinal detachment and endophthalmitis.[59] In both cases, patients notice a sudden decrease in vision. In endophthalmitis, patients often describe pain. Retinal detachment frequently presents with unilateral visual field defects, blurring of vision, flashes of light, or floating spots.[citation needed]

The risk of retinal detachment was estimated as about 0.4% within 5.5 years, corresponding to a 2.3-fold risk increase compared to naturally expected incidence, with older studies reporting a substantially higher risk. The incidence is increasing over time in a somewhat linear manner, and the risk increase lasts for at least 20 years after the procedure. Particular risk factors are younger age, male sex, longer axial length, and complications during surgery. In the highest risk group of patients, the incidence of pseudophakic retinal detachment may be as high as 20%.[60]

The risk of endophthalmitis occurring after surgery is less than one in 1000.[61]

Corneal edema and cystoid macular edema are less serious but more common, and occur because of persistent swelling at the front of the eye in corneal edema or back of the eye in cystoid macular edema.[62] They are normally the result of excessive inflammation following surgery, and in both cases, patients may notice blurred, foggy vision. They normally improve with time and with application of anti-inflammatory drops. The risk of either occurring is around one in 100. It is unclear whether NSAIDs or corticosteroids are superior at reducing postoperative inflammation.[63]

Posterior capsular opacification, also known as after-cataract, is a condition in which months or years after successful cataract surgery, vision deteriorates or problems with glare and light scattering recur, usually due to thickening of the back or posterior capsule surrounding the implanted lens, so-called 'posterior lens capsule opacification'. Growth of natural lens cells remaining after the natural lens was removed may be the cause, and the younger the patient, the greater the chance of this occurring. Management involves cutting a small, circular area in the posterior capsule with targeted beams of energy from a laser, called Nd capsulotomy, after the type of laser used. The laser can be aimed very accurately, and the small part of the capsule which is cut falls harmlessly to the bottom of the inside of the eye. This procedure leaves sufficient capsule to hold the lens in place, but removes enough to allow light to pass directly through to the retina. Serious side effects are rare.[64] Posterior capsular opacification is common and occurs following up to one in four operations, but these rates are decreasing following the introduction of modern intraocular lenses together with a better understanding of the causes.[citation needed]

Vitreous touch syndrome is a possible complication of intracapsular cataract extraction.[65]

Epidemiology

Disability-adjusted life years for cataracts per 100,000 inhabitants in 2004:[66]

Age-related cataracts are responsible for 51% of world blindness, about 20 million people.[67] Globally, cataracts cause moderate to severe disability in 53.8 million (2004), 52.2 million of whom are in low and middle income countries.[68]

In many countries, surgical services are inadequate, and cataracts remain the leading cause of blindness.[67] Even where surgical services are available, low vision associated with cataracts may still be prevalent as a result of long waits for, and barriers to, surgery, such as cost, lack of information and transportation problems.

In the United States, age-related lens changes have been reported in 42% between the ages of 52 and 64,[69] 60% between the ages 65 and 74,[70] and 91% between the ages of 75 and 85.[69] Cataracts affect nearly 22 million Americans age 40 and older. By age 80, more than half of all Americans have cataracts. Direct medical costs for cataract treatment are estimated at $6.8 billion annually.[71]

In the eastern Mediterranean region, cataracts are responsible for over 51% of blindness. Access to eye care in many countries in this region is limited.[72] Childhood-related cataracts are responsible for 5–20% of world childhood blindness.[73]

Vision loss due to cataracts increases the risk of dementia in the elderly population, increases the likelihood of falls and road traffic accidents, and by detrimental effects on the quality of life increases mortality.[74]

History

Cataract surgery was first described by the Ayurvedic physician, Suśruta (about 5th century BCE) in Sushruta Samhita in ancient India. Most of the methods mentioned focus on hygiene. Follow-up treatments include bandaging of the eye and covering the eye with warm butter.[75] References to cataracts and their treatment in Ancient Rome are also found in 29 AD in De Medicinae, the work of the Latin encyclopedist Aulus Cornelius Celsus.[76] Archaeological evidence of eye surgery in the Roman era also exists.[77]

Galen of Pergamon (ca. 2nd century CE), a prominent Greek physician, surgeon and philosopher, performed an operation similar to modern cataract surgery. Using a needle-shaped instrument, Galen attempted to remove the cataract-affected lens of the eye.[78]

Muslim ophthalmologist Ammar Al-Mawsili, in his The Book of Choice in Ophthalmology, written circa 1000 CE, wrote of his invention of a syringe and the technique of cataract extraction while experimenting with it on a patient.[79]

In 1468 Abiathar Crescas, a Jewish physician and astrologer of the Crown of Aragon, famously removed the cataracts of King John II of Aragon, restoring his eyesight.

Etymology

"Cataract" is derived from the Latin cataracta, meaning "waterfall", and from the Ancient Greek καταρράκτης (katarrhaktēs), "down-rushing",[80] from καταράσσω (katarassō) meaning "to dash down"[81] (from kata-, "down"; arassein, "to strike, dash").[82][83] As rapidly running water turns white, so the term may have been used metaphorically to describe the similar appearance of mature ocular opacities. In Latin, cataracta had the alternative meaning "portcullis"[84] and the name possibly passed through French to form the English meaning "eye disease" (early 15th century), on the notion of "obstruction".[85] Early Persian physicians called the term nazul-i-ah, or "descent of the water"—vulgarised into waterfall disease or cataract—believing such blindness to be caused by an outpouring of corrupt humour into the eye.[86]

Research

N-Acetylcarnosine drops have been investigated as a medical treatment for cataracts. The drops are believed to work by reducing oxidation and glycation damage in the lens, particularly reducing crystallin crosslinking.[87][88] Some benefit has been shown in small manufacturer-sponsored randomized controlled trials but further independent corroboration is still required.[89]

Femtosecond laser mode-locking, used during cataract surgery, was originally used to cut accurate and predictable flaps in LASIK surgery, and has been introduced to cataract surgery. The incision at the junction of the sclera and cornea and the hole in capsule during capsulorhexis, traditionally made with a handheld blade, needle, and forceps, are dependent on skill and experience of the surgeon. Sophisticated three-dimensional images of the eyes can be used to guide lasers to make these incisions. A Nd can also then break up the cataract as in phacoemulsification.[90]

Stem cells have been used in a clinical trial, with results submitted in 2014 and published in March 2016, for lens regeneration in twelve children under the age of two with cataracts present at birth.[91] The children were followed for six months, so it is unknown what the long-term results have been, and it is unknown if this procedure would work in adults.[91]

See also

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 "Facts About Cataract". September 2009. http://www.nei.nih.gov/health/cataract/cataract_facts. 
  2. ↑ 2.0 2.1 "Consequences of waiting for cataract surgery". Current Opinion in Ophthalmology 22 (1): 28–30. January 2011. doi:10.1097/icu.0b013e328341425d. PMID 21076306. 
  3. ↑ 3.0 3.1 "Visual impairment and blindness Fact Sheet N°282". August 2014. https://www.who.int/mediacentre/factsheets/fs282/en/. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Priority eye diseases". https://www.who.int/blindness/causes/priority/en/index1.html. 
  5. ↑ "Congenital and infantile cataract: aetiology and management". European Journal of Pediatrics 171 (4): 625–630. April 2012. doi:10.1007/s00431-012-1700-1. PMID 22383071. 
  6. ↑ Vos, Theo et al. (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMID 27733282. 
  7. ↑ 7.0 7.1 M. Edward Wilson, Jr.; Rupal H. Trivedi; Suresh K. Pandey (2005). Pediatric cataract surgery techniques, complications, and management. Philadelphia: Lippincott Williams & Wilkins. p. 20. ISBN 978-0781743075. https://books.google.com/books?id=gLJZDD2igCMC&pg=PA20. 
  8. ↑ "Cataract and surgery for cataract". BMJ 333 (7559): 128–132. July 2006. doi:10.1136/bmj.333.7559.128. PMID 16840470. 
  9. ↑ Global Data on Visual Impairments 2010. WHO. 2012. p. 6. https://www.who.int/blindness/GLOBALDATAFINALforweb.pdf?ua=1. 
  10. ↑ "Recognizing Cataracts". 2017-05-30. https://newsinhealth.nih.gov/2013/08/recognizing-cataracts. "Try wearing sunglasses or a hat with a brim. Researchers also believe that good nutrition can help reduce the risk of age-related cataract. They recommend eating plenty of green leafy vegetables, fruits, nuts and other healthy foods." 
  11. ↑ "The impact of cataract surgery on quality of life". Current Opinion in Ophthalmology 22 (1): 19–27. January 2011. doi:10.1097/icu.0b013e3283414284. PMID 21088580. 
  12. ↑ 12.0 12.1 "The global burden of cataract". Current Opinion in Ophthalmology 22 (1): 4–9. January 2011. doi:10.1097/icu.0b013e3283414fc8. PMID 21107260. 
  13. ↑ 13.0 13.1 "Cataract Data and Statistics". National Eye Institute. https://www.nei.nih.gov/learn-about-eye-health/resources-for-health-educators/eye-health-data-and-statistics/cataract-data-and-statistics. 
  14. ↑ "Posterior Supcapsular Cataract". Digital Reference of Ophthalmology. Edward S. Harkness Eye Institute, Department of Ophthalmology of Columbia University. 2003. http://dro.hs.columbia.edu/lc1.htm. 
  15. ↑ "Updates on managements of pediatric cataract". Journal of Current Ophthalmology 31 (2): 118–126. June 2019. doi:10.1016/j.joco.2018.11.005. PMID 31317088. 
  16. ↑ 16.0 16.1 16.2 Ophthalmology. St. Louis, Mo: Mosby/Elsevier. 2009. ISBN 978-0-323-04332-8. [page needed]
  17. ↑ 17.0 17.1 17.2 Hsueh, Yi-Jen; Chen, Yen-Ning; Tsao, Yu-Ting; Cheng, Chao-Min; Wu, Wei-Chi; Chen, Hung-Chi (2022). "The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases". International Journal of Molecular Sciences 23 (3): 1255. doi:10.3390/ijms23031255. PMID 35163178. 
  18. ↑ Njie-Mbye, Ya Fatou; Chitnis, Madhura; Opere, Catherine; Ohia, Sunny (January 18, 2013). "Lipid peroxidation: pathophysiological and pharmacological implications in the eye". Frontiers in Physiology 4. doi:10.3389/fphys.2013.00366. 
  19. ↑ "Electric cataract: a case report and review of the literature". European Journal of Ophthalmology 9 (2): 134–138. 1999. doi:10.1177/112067219900900211. PMID 10435427. 
  20. ↑ "IMAGES IN CLINICAL MEDICINE. Petaloid Cataract". The New England Journal of Medicine 374 (18): e22. May 2016. doi:10.1056/NEJMicm1507349. PMID 27144871. 
  21. ↑ 21.0 21.1 "Cataracts induced by microwave and ionizing radiation". Survey of Ophthalmology 33 (3): 200–210. 1988. doi:10.1016/0039-6257(88)90088-4. PMID 3068822. 
  22. ↑ "UV radiation ocular exposure dosimetry". Documenta Ophthalmologica. Advances in Ophthalmology 88 (3–4): 243–254. 1994. doi:10.1007/bf01203678. PMID 7634993. 
  23. ↑ "Molecular Genetics of Cataract", Genetics in Ophthalmology, Karger Medical and Scientific Publishers, 2003, p. 77, ISBN 978-3805575782 
  24. ↑ Ophthalmology, Elsevier Health Sciences, 2009, p. 507, ISBN 978-0323043328 
  25. ↑ Ye J, He J, Wang C, Wu H, Shi X, Zhang H, Xie J, Lee SY. (2012). "Smoking and risk of age-related cataract: a meta-analysis". Invest Ophthalmol Vis Sci 53 (7): 3885–95. doi:10.1167/iovs.12-9820. PMID 22599585. 
  26. ↑ Beltrán-Zambrano E, García-Lozada D, Ibáñez-Pinilla E. (2019). "Risk of cataract in smokers: A meta-analysis of observational studies". Arch Soc Esp Oftalmol (Engl Ed) 94 (2): 60–74. doi:10.1016/j.oftal.2018.10.020. PMID 30528895. 
  27. ↑ "Alcohol and eye diseases". Survey of Ophthalmology 53 (5): 512–525. 2008. doi:10.1016/j.survophthal.2008.06.003. PMID 18929762. 
  28. ↑ "Association of vitamin C with the risk of age-related cataract: a meta-analysis". Acta Ophthalmologica 94 (3): e170–e176. May 2016. doi:10.1111/aos.12688. PMID 25735187. 
  29. ↑ 29.0 29.1 "Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract". The Cochrane Database of Systematic Reviews 6 (6): CD004567. June 2012. doi:10.1002/14651858.CD004567.pub2. PMID 22696344. 
  30. ↑ "Dose-response relationship of inhaled corticosteroids and cataracts: a systematic review and meta-analysis". Respirology 14 (7): 983–990. September 2009. doi:10.1111/j.1440-1843.2009.01589.x. PMID 19740259. 
  31. ↑ 31.0 31.1 "Risk factors for age-related cataracts". Epidemiologic Reviews 17 (2): 336–346. 1995. doi:10.1093/oxfordjournals.epirev.a036197. PMID 8654515. 
  32. ↑ "Side effects of atypical antipsychotics: a brief overview". World Psychiatry 7 (1): 58–62. February 2008. doi:10.1002/j.2051-5545.2008.tb00154.x. PMID 18458771. 
  33. ↑ "[Drug-induced cataracts]" (in fr). Revue Médicale de Liège 53 (12): 766–769. December 1998. PMID 9927876. 
  34. ↑ "Triperanol". MeSH. National Library of Medicine. https://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?mode=&term=Triparanol&field=entry. 
  35. ↑ "Small-gauge vitrectomy does not protect against nuclear sclerotic cataract". Retina 32 (3): 499–505. March 2012. doi:10.1097/IAE.0b013e31822529cf. PMID 22392091. 
  36. ↑ "Biochemical analysis of the living human vitreous". Clinical & Experimental Ophthalmology 44 (7): 597–609. September 2016. doi:10.1111/ceo.12732. PMID 26891415. 
  37. ↑ "Vitreous substitutes: the present and the future". BioMed Research International 2014: 351804. 2014. doi:10.1155/2014/351804. PMID 24877085. 
  38. ↑ "The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts". Archives of Ophthalmology 127 (4): 475–482. April 2009. doi:10.1001/archophthalmol.2008.621. PMID 19365028. 
  39. ↑ "Microincision cataract surgery combined with vitrectomy: a case series". Eye 28 (4): 386–389. April 2014. doi:10.1038/eye.2013.300. PMID 24406418. 
  40. ↑ Bennett, Michael H.; Cooper, Jeffrey S. (10 August 2022). Hyperbaric Cataracts. StatPearls Publishing LLC.. PMID 29261974. https://www.ncbi.nlm.nih.gov/books/NBK470454/. Retrieved 27 February 2023. 
  41. ↑ Aliancy, Joah F.; Mamalis, Nick (1995), Kolb, Helga; Fernandez, Eduardo; Nelson, Ralph, eds., "Crystalline Lens and Cataract", Webvision: The Organization of the Retina and Visual System (Salt Lake City (UT): University of Utah Health Sciences Center), PMID 29356473, http://www.ncbi.nlm.nih.gov/books/NBK476171/, retrieved 2023-04-24 
  42. ↑ 42.0 42.1 42.2 42.3 "What can patients expect from cataract surgery?". Cleveland Clinic Journal of Medicine 75 (3): 193–96, 199–200. March 2008. doi:10.3949/ccjm.75.3.193. PMID 18383928. 
  43. ↑ "Steroid cataracts. Posterior subcapsular cataract formation in rheumatoid arthritis patients on long term steroid therapy". Archives of Ophthalmology 74: 38–41. July 1965. doi:10.1001/archopht.1965.00970040040009. PMID 14303339. 
  44. ↑ "Posterior subcapsular cataracts: histopathologic study of steroid-associated cataracts". Archives of Ophthalmology 97 (1): 135–144. January 1979. doi:10.1001/archopht.1979.01020010069017. PMID 758890. 
  45. ↑ Ophthalmology (3rd ed.). Edinburgh: Mosby. 2008. p. 412. ISBN 978-0323057516. 
  46. ↑ "Sun exposure as a risk factor for nuclear cataract". Epidemiology 14 (6): 707–712. November 2003. doi:10.1097/01.ede.0000086881.84657.98. PMID 14569187. 
  47. ↑ "Blindness due to cataract: epidemiology and prevention". Annual Review of Public Health 17: 159–177. 1996. doi:10.1146/annurev.pu.17.050196.001111. PMID 8724222.  Cited in Five-Year Agenda for the National Eye Health Education Program (NEHEP), p. B-2; National Eye Institute, U.S. National Institutes of Health
  48. ↑ "Dietary supplementation: effects on visual performance and occurrence of AMD and cataracts". Current Medical Research and Opinion 26 (8): 2011–2023. August 2010. doi:10.1185/03007995.2010.494549. PMID 20590393. 
  49. ↑ "A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie 252 (1): 63–70. January 2014. doi:10.1007/s00417-013-2492-3. PMID 24150707. 
  50. ↑ "The Effects of Lutein in Preventing Cataract Progression". Studies on the Cornea and Lens. Oxidative Stress in Applied Basic Research and Clinical Practice. 2014-11-01. pp. 317–26. doi:10.1007/978-1-4939-1935-2_17. ISBN 9781493919345. 
  51. ↑ 51.0 51.1 Vaughan & Asbury's general ophthalmology. (18th ed.). McGraw-Hill Medical. 2011. ISBN 978-0071634205. [page needed]
  52. ↑ "Focussing both eyes on health outcomes: revisiting cataract surgery". BMC Geriatrics 12: 50. September 2012. doi:10.1186/1471-2318-12-50. PMID 22943071.  open access
  53. ↑ "Is there overutilisation of cataract surgery in England?". The British Journal of Ophthalmology 93 (1): 13–17. January 2009. doi:10.1136/bjo.2007.136150. PMID 19098042. http://eprints.gla.ac.uk/5530/1/5530.pdf. 
  54. ↑ Studies on the Cornea and Lens, Springer, 2014, p. 4, ISBN 978-1493919352 
  55. ↑ Essential Principles of Phacoemulsification, JP Medical Ltd, 2013, ISBN 978-9962678618 [page needed]
  56. ↑ "Different-sized incisions for phacoemulsification in age-related cataract". The Cochrane Database of Systematic Reviews 2017 (9): CD010510. September 2017. doi:10.1002/14651858.CD010510.pub2. PMID 28931202. 
  57. ↑ "Extracapsular Cataract Extraction", Essentials of Cataract Surgery, Slack, 2007, p. 187, ISBN 978-1556428029 
  58. ↑ The Eye in History, JP Medical, 2013, p. 367, ISBN 978-9350902745 
  59. ↑ "Complications After Cataract Surgery", Applied Pathology for Ophthalmic Microsurgeons, Springer Science & Business, 2008, p. 247, ISBN 978-3540683667 
  60. ↑ "[Pseudophakic retinal detachment]". Klinische Monatsblätter für Augenheilkunde 228 (3): 195–200. March 2011. doi:10.1055/s-0029-1246116. PMID 21374539. 
  61. ↑ "One million cataract surgeries: Swedish National Cataract Register 1992-2009". Journal of Cataract and Refractive Surgery 37 (8): 1539–1545. August 2011. doi:10.1016/j.jcrs.2011.05.021. PMID 21782099. 
  62. ↑ Ophthalmology Secrets in Color, Elsevier Health Sciences, 2015, p. 221, ISBN 978-0323378024 
  63. ↑ "Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery". The Cochrane Database of Systematic Reviews 2017 (7): CD010516. July 2017. doi:10.1002/14651858.CD010516.pub2. PMID 28670710. 
  64. ↑ "Posterior capsule opacification – why laser treatment is sometimes needed following cataract surgery". rnib.org.uk. 2014-02-19. http://www.rnib.org.uk/eyehealth/eyeconditions/conditionsac/Pages/cataract_lasersurgery.aspx. 
  65. ↑ "A review and clinical evaluation of per-operative and post-operative complications in case of manual small incision cataract surgery and extracapsular cataract extraction with posterior chamber intra-ocular lens implantation". 2006. http://14.139.159.4:8080/jspui/bitstream/123456789/1638/1/CDMOPTH00032.pdf. 
  66. ↑ "Death and DALY estimates for 2004 by cause for WHO Member States" (xls). World Health Organization. who.int. 2004. https://www.who.int/entity/healthinfo/global_burden_disease/gbddeathdalycountryestimates2004.xls. 
  67. ↑ 67.0 67.1 "Priority eye diseases: Cataract". Prevention of Blindness and Visual Impairment. World Health Organization. https://www.who.int/blindness/causes/priority/en/index1.html. 
  68. ↑ The global burden of disease : 2004 update.. Geneva, Switzerland: World Health Organization. 2008. p. 35. ISBN 978-9241563710. 
  69. ↑ 69.0 69.1 "Senile lens and senile macular changes in a population-based sample". American Journal of Ophthalmology 90 (1): 86–91. July 1980. doi:10.1016/s0002-9394(14)75081-0. PMID 7395962. 
  70. ↑ "The Framingham Eye Study. I. Outline and major prevalence findings". American Journal of Epidemiology 106 (1): 17–32. July 1977. doi:10.1093/oxfordjournals.aje.a112428. PMID 879158. 
  71. ↑ "Eye Health Statistics at a Glance". http://www.aao.org/newsroom/upload/Eye-Health-Statistics-April-2011.pdf. 
  72. ↑ "Health Topics: Cataract". World Health Organization – Eastern Mediterranean Regional Office. http://www.emro.who.int/health-topics/cataract/. 
  73. ↑ "Cataracts". Lancet 390 (10094): 600–612. August 2017. doi:10.1016/S0140-6736(17)30544-5. PMID 28242111. 
  74. ↑ Fang, Rui; Yu, Yang-Fan; Li, En-Jie; Lv, Ning-Xin; Liu, Zhao-Chuan; Zhou, Hong-Gang; Song, Xu-Dong (2022). "Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019". BMC Public Health 22 (2068): 2068. doi:10.1186/s12889-022-14491-0. PMID 36369026. 
  75. ↑ (in en) The Eye in History. JP Medical Ltd. 2013. p. 371. ISBN 978-9350902745. https://books.google.com/books?id=v0oL8xDJ0VEC&pg=PA371. 
  76. ↑ De Medicinae. 1831. 
  77. ↑ "The Romans carried out cataract ops". BBC News. February 9, 2008. http://news.bbc.co.uk/2/hi/health/7194352.stm. 
  78. ↑ "Galen: On Anatomical Procedures: the Later Books". Med Hist 7 (1): 85–87. 1963. doi:10.1017/s002572730002799x. 
  79. ↑ Origins of Neuroscience: A History of Explorations Into Brain Function. Oxford University Press. 1994. p. 70. ISBN 978-0-19-514694-3. 
  80. ↑ Liddell, Henry George; Scott, Robert. "καταρράκτης". A Greek-English Lexicon. https://www.perseus.tufts.edu/hopper/text?doc=Perseus%3Atext%3A1999.04.0057%3Aentry%3Dkatarra%2Fkths. 
  81. ↑ Liddell, Henry George; Scott, Robert. "καταράσσω". A Greek-English Lexicon. https://www.perseus.tufts.edu/hopper/text?doc=Perseus%3Atext%3A1999.04.0057%3Aentry%3Dkatara%2Fssw. 
  82. ↑ "cataract". Dictionary.com. Dictionary.com, LLC. https://www.dictionary.com/browse/cataract. 
  83. ↑ "cataract". Oxford Dictionaries. Oxford University Press. http://oxforddictionaries.com/definition/english/cataract. 
  84. ↑ Lewis, Charlton T.; Short, Charles. "cataracta". A Latin Dictionary. https://www.perseus.tufts.edu/hopper/text?doc=Perseus%3Atext%3A1999.04.0059%3Aentry%3Dcataracta. 
  85. ↑ "cataract". http://www.etymonline.com/index.php?term=cataract. 
  86. ↑ Mistaken Science – Topic Powered by eve community , Wordcraft Forums, wordcraft.infopop.cc
  87. ↑ "The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study". Veterinary Ophthalmology 9 (5): 311–316. 2006. doi:10.1111/j.1463-5224.2006.00492.x. PMID 16939459. 
  88. ↑ "[Preventive effect of carnosine on cataract development]". Yan Ke Xue Bao = Eye Science 22 (2): 85–88. June 2006. PMID 17162883. 
  89. ↑ "Medical treatment of cataract". Clinical & Experimental Ophthalmology 35 (7): 664–671. 2007. doi:10.1111/j.1442-9071.2007.01559.x. PMID 17894689. 
  90. ↑ "Femtosecond laser capsulotomy". Journal of Cataract and Refractive Surgery 37 (7): 1189–1198. July 2011. doi:10.1016/j.jcrs.2011.04.022. PMID 21700099.  as PDF The authors declare a financial interest in a company producing femtosecond laser equipment.
  91. ↑ 91.0 91.1 "Stem cells used to repair children's eyes after cataracts". NHS. March 10, 2016. http://www.nhs.uk/news/2016/03March/Pages/Childrens-eyes-damaged-by-cataracts-repaired-by-stem-cells.aspx. 

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