Chemistry:MLD-41

From HandWiki

MLD-41, also known as 1-methyl-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It has about 33% of the psychoactive potency of LSD.[1][2] It has been studied with regard to cross-tolerance with LSD.[3] Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed.[4][5]

Interactions

See also

  • Substituted lysergamide
  • MLA-74 (1-methyl-LAE)
  • MPD-75 (1-methyl-LPD)
  • MBL-61 (1-methyl-2-bromo-LSD)

References

  1. ↑ 1.0 1.1 "Structure-activity relationships of the classic hallucinogens and their analogs". NIDA Res Monogr 146: 74–91. 1994. PMID 8742795. https://archives.nida.nih.gov/sites/default/files/monograph146.pdf#page=79. 
  2. ↑ 2.0 2.1 "D-Lysergic acid diethylamide (LSD): A review of its present status". Clin Pharmacol Ther 6: 183–255. 1965. doi:10.1002/cpt196562183. PMID 14288188. 
  3. ↑ "Production of cross-tolerance to psychosis-producing doses of lysergic acid diethylamide and psilocybin.". The Journal of Psychology 49 (1): 151–154. January 1960. doi:10.1080/00223980.1960.9916396. 
  4. ↑ "Multipotent and Poly-therapeutic Fungal Alkaloids of Claviceps purpurea". Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World. 4. 2017. pp. 229–252. doi:10.1007/978-981-10-5978-0_8. ISBN 978-981-10-5977-3. "Metabolites of methysergide also exhibit pharmacological activity. Methylergometrine (one of methysergide’s metabolites) is responsible for methysergide’s therapeutic effects regarding migraine treatment (Müller-Schweinitzer and Tapparelli 1986). [...] The systemic availability of methysergide after oral administration is only 13%, due to a high degree of first-pass metabolism by N-1 demethylation to methylergometrine. After oral administration, the plasma concentrations of the metabolite are considerably higher than those of the parent drug, and the area under the plasma concentration curve (AUC) for methylergometrine is more than ten times greater than for methysergide." 
  5. ↑ "Methylergometrine, an active metabolite of methysergide". Cephalalgia: An International Journal of Headache 6 (1): 35–41. March 1986. doi:10.1046/j.1468-2982.1986.0601035.x. PMID 3698092. 

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