Chemistry:LAMPA

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Lysergic acid methylpropylamide (LAMPA, LAMP, or LMP), also known as LMP-55 or as N-methyl-N-propyllysergamide (MPLA), is a structural analogue of lysergic acid diethylamide (LSD) that has been studied as a potential treatment for alcoholism.[1] In animal studies, LAMPA was found to be nearly equipotent to ECPLA and MIPLA for inducing a head-twitch response. LAMPA appears to be significantly less potent than LSD in humans, producing little to no noticeable effects at doses of 100 μg.[2] It shows reduced-efficacy partial agonism of the serotonin 5-HT2A receptor relative to LSD, which may be responsible for its equivocal hallucinogenic effects.[3]

See also

References

  1. ↑ "Comparison of LSD with methysergide and psilocybin on test subjects.". The use of LSD in psychotherapy and alcoholism.. Bobbs-Merrill Company Inc.. 1967. pp. 53–57. https://www.samorini.it/doc1/alt_aut/ad/abramson-the-use-of-lsd-in-psychotherapy-and-alcoholism.pdf. Retrieved 15 May 2022. 
  2. ↑ "Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA)". Psychopharmacology 236 (2): 799–808. February 2019. doi:10.1007/s00213-018-5055-9. PMID 30298278. 
  3. ↑ "Differential in Vitro Activation Profiles for Psychedelic versus Non-psychedelic Ergolines at the 5-HT2A Receptor". Emerging Trends in Drugs, Addictions, and Health 4. 2024. doi:10.1016/j.etdah.2023.100109. 

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