Chemistry:LSM-775

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LSM-775, also known as N-morpholinyllysergamide or as lysergic acid morpholide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1]

Use and effects

LSM-775 is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 700 μg and a shorter duration.[2] It may only produce weak or threshold psychedelic effects in humans.[3] There are claimed to be fewer signs of cardiovascular stimulation and peripheral toxicity with LSM-775 compared to LSD.[2]

Interactions

Pharmacology

Pharmacodynamics

LSM-775 is a potent full agonist of the serotonin 5-HT1A receptor and a potent partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.[3] It does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[3] However, LSM-775 can robustly increase head twitches if it is coadministered with the serotonin 5-HT1A receptor antagonist WAY-100635.[3] These findings indicate that serotonin 5-HT1A receptor activation suppresses the psychedelic-like effects of LSM-775.[3]

History

LSM-775 was first described in the scientific literature by Albert Hofmann and colleagues by 1955.[4]

See also

References

  1. ↑ "Pharmacology of d-lysergic acid morpholide (LSM)". The Journal of Pharmacology and Experimental Therapeutics 120 (3): 340–348. July 1957. doi:10.1016/S0022-3565(25)23282-7. PMID 13476356. http://jpet.aspetjournals.org/content/120/3/340.abstract. 
  2. ↑ 2.0 2.1 "TiHKAL #26, LSD-25". Erowid. https://www.erowid.org/library/books_online/tihkal/tihkal26.shtml. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775)". Drug Testing and Analysis 10 (2): 310–322. February 2018. doi:10.1002/dta.2222. PMID 28585392. 
  4. ↑ "Amide der stereoisomeren Lysergsäuren und Dihydro-lysergsäuren. 38. Mitteilung über Mutterkornalkaloide". Helvetica Chimica Acta 38 (2): 421–433. 1955. doi:10.1002/hlca.19550380207. ISSN 0018-019X. Bibcode: 1955HChAc..38..421S. https://onlinelibrary.wiley.com/doi/10.1002/hlca.19550380207. Retrieved 5 June 2025. 

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