Chemistry:BU-LAD
BU-LAD, also known as 6-butyl-6-nor-LSD or 6-butyl-6-nor-lysergic acid diethylamide, is a psychedelic drug and analogue of lysergic acid diethylamide (LSD) first described by David E. Nichols and colleagues in the 1980s.[1][2]
Use and effects
According to Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved), BU-LAD is a psychedelic drug similar to LSD, but is significantly less potent than LSD, with a dose of 500 μg orally producing only mild effects.[3]
Interactions
Pharmacology
Pharmacodynamics
BU-LAD substitutes for LSD in rodent drug discrimination tests.[4] However, it has 13-fold reduced potency relative to LSD itself and 37- to 42-fold lower potency than ETH-LAD and AL-LAD in this test.[4]
Chemistry
Analogues
Analogues of BU-LAD include LSD, ETH-LAD, PRO-LAD, AL-LAD, PARGY-LAD, and MAL-LAD, among others.
See also
- Substituted lysergamide
References
- ↑ "Stereochemical Aspects of Hallucinogenesis". Biochemistry and Physiology of Substance Abuse. 3. Boca Raton, Fla.: CRC Press. 1991. pp. 1–39. ISBN 978-0-8493-4463-3. OCLC 26748320. https://bitnest.netfirms.com/external/Books/BiochemistryPhysiologySubstanceAbuse3.1. "TABLE 1 Effects of N-(6)-Alkyl Subtituents on LSD-Like Behavior and Serotonin Receptor Affinity in Rats [...]"
- ↑ "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry 28 (9): 1252–5. September 1985. doi:10.1021/jm00147a022. PMID 4032428.
- ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml.
- ↑ 4.0 4.1 "Use of Chemical Approaches to Probe Serotonin Receptor Topography". International Symposium on Medicinal Chemistry Proceedings. 12. 1985. pp. 103–115. https://chemistry.mdma.ch/hiveboard/rhodium/pdf/nichols/nichols-5-ht.receptor.topography.probes.pdf.
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