Chemistry:1B-LSD

From HandWiki

1B-LSD, also known as 1-butyryl-LSD, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug.[1]

Use and effects

Interactions

Pharmacology

Pharmacodynamics

1B-LSD has been found to produce psychedelic-like effects in rodents similarly to LSD, though with only around 1/7 the potency of LSD itself.[2][3][4]

Chemistry

Analogues

Related compounds include 1cP-LSD, 1P-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others.

Society and culture

Canada

1B-LSD is not a controlled substance in Canada as of 2025.[5]

Singapore

1B-LSD is illegal in Singapore.[6] Sweden's public health agency suggested classifying 1B-LSD as a hazardous substance, on June 24, 2019.[7]

United States

1B-LSD is not an explicitly controlled substance in the United States.[8] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ↑ "Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics". Molecules 25 (3): 712. February 2020. doi:10.3390/molecules25030712. PMID 32045999. 
  2. ↑ "In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures". Analytical and Bioanalytical Chemistry 411 (19): 4751–4763. July 2019. doi:10.1007/s00216-018-1558-9. PMID 30617391. http://researchonline.ljmu.ac.uk/id/eprint/9841/13/ABC-01967-2018_02_accepted.pdf. 
  3. ↑ "Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD)". Drug Testing and Analysis 11 (8): 1122–1133. August 2019. doi:10.1002/dta.2613. PMID 31083768. 
  4. ↑ "Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)". Neuropharmacology 172. August 2020. doi:10.1016/j.neuropharm.2019.107856. PMID 31756337. PMC 9191647. https://researchonline.ljmu.ac.uk/id/eprint/11815/1/NEUROPHARM-D-19-00561R1_accepted_uncorrected.pdf. 
  5. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  6. ↑ "Misuse of Drugs Act - Singapore Statutes Online". https://sso.agc.gov.sg/Act/MDA1973. 
  7. ↑ "Åtta ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. 24 June 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/juni/atta-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/. 
  8. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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