Biology:GNGT2
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 Generic protein structure example |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a protein that in humans is encoded by the GNGT2 gene.[1][2]
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. There is evidence for use of multiple polyadenylation sites by this gene.[2]
References
- ↑ "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)". Genomics 44 (1): 101–9. Nov 1997. doi:10.1006/geno.1997.4814. PMID 9286705.
- ↑ 2.0 2.1 "Entrez Gene: GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2793.
Further reading
- Cohen NA; Sha Q; Makhina EN et al. (1997). "Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits". J. Biol. Chem. 271 (50): 32301–5. doi:10.1074/jbc.271.50.32301. PMID 8943291.
- "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8. 1997. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307.
- Cook LA; Schey KL; Cleator JH et al. (2002). "Identification of a region in G protein γ subunits conserved across species but hypervariable among subunit isoforms". Protein Sci. 10 (12): 2548–55. doi:10.1110/ps.ps.26401. PMID 11714923.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Cuello F; Schulze RA; Heemeyer F et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
- Ivanina T; Rishal I; Varon D et al. (2003). "Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel". J. Biol. Chem. 278 (31): 29174–83. doi:10.1074/jbc.M304518200. PMID 12743112.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- DePuy SD; Yao J; Hu C et al. (2006). "The molecular basis for T-type Ca2+ channel inhibition by G protein β2γ2 subunits". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14590–5. doi:10.1073/pnas.0603945103. PMID 16973746. Bibcode: 2006PNAS..10314590D.
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