Biology:p21-activated kinases

From HandWiki

p21 activated kinases (PAKs) are members of a family of enzymes.[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

  • PAK1, regulating cell motility and morphology[2]
  • PAK2, possibly playing a role in apoptosis[3]
  • PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity[4]
  • PAK4, a mediator of filopodia formation[5]
  • PAK5, a mediator of filopodia formation[6]
  • PAK6, involved in cytoskeleton rearrangement[7]

References

  1. ↑ p21-Activated+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ↑ "Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5058. 
  3. ↑ "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5062. 
  4. ↑ "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5063. 
  5. ↑ "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10298. 
  6. ↑ "PAK5 p21 (RAC1) activated kinase 5 [Homo sapiens (human)] - Gene - NCBI". https://www.ncbi.nlm.nih.gov/gene/57144. 
  7. ↑ "PAK6 p21 (RAC1) activated kinase 6 [Homo sapiens (human)] - Gene - NCBI". https://www.ncbi.nlm.nih.gov/gene/56924. 

External links




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