Biology:3',5'-cyclic-AMP phosphodiesterase
From HandWiki
Short description: Class of enzymes
| 3′,5′-cyclic-AMP phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase.[1][2][3][4][5][6] It catalyses the following reaction
- adenosine 3′,5′-cyclic phosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] AMP
This enzyme requires Mg2+ or Mn2+ for activity.
References
- ↑ "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology 145 (1): 40–9. January 2006. doi:10.1016/j.molbiopara.2005.09.005. PMID 16225937.
- ↑ "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". The Journal of Biological Chemistry 281 (29): 20018–26. July 2006. doi:10.1074/jbc.M600040200. PMID 16644729.
- ↑ "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America 99 (7): 4714–9. April 2002. doi:10.1073/pnas.002031599. PMID 11930017. Bibcode: 2002PNAS...99.4714R.
- ↑ "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology 6: 25. March 2006. doi:10.1186/1471-2180-6-25. PMID 16522215.
- ↑ "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects 1472 (3): 431–446. November 1999. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
- ↑ "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry 271 (41): 25423–9. October 1996. doi:10.1074/jbc.271.41.25423. PMID 8810311.
External links
- 3',5'-cyclic-AMP+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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