Biology:MED4
From HandWiki
 Generic protein structure example |
| Med4 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med4 | ||||||||
| Pfam | PF10018 | ||||||||
| InterPro | IPR019258 | ||||||||
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Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.[1][2][3]
Function
The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.[2]
Interactions
MED4 has been shown to interact with MED25.[4]
References
- ↑ "Entrez Gene: MED4 mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29079.
- ↑ 2.0 2.1 "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8. April 1999. doi:10.1038/19783. PMID 10235266. Bibcode: 1999Natur.398..824R.
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. October 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. Feb 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
Further reading
- "The mammalian Mediator complex.". FEBS Lett. 579 (4): 904–8. 2005. doi:10.1016/j.febslet.2004.11.031. PMID 15680972.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. 1999. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
- "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. 1999. doi:10.1038/19783. PMID 10235266. Bibcode: 1999Natur.398..824R.
- "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. 1999. doi:10.1038/19789. PMID 10235267. Bibcode: 1999Natur.398..828N.
- "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.". Mol. Cell 5 (4): 753–60. 2000. doi:10.1016/S1097-2765(00)80254-3. PMID 10882111.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
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