Medicine:Gastritis

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Short description: Stomach disease that is an inflammation of the lining of the stomach
Gastritis
Gastritis helicobacter - intermed mag.jpg
Micrograph showing gastritis. H&E stain.
SpecialtyGastroenterology
SymptomsUpper abdominal pain, nausea, vomiting, bloating, loss of appetite, heartburn[1][2]
ComplicationsBleeding, stomach ulcers, stomach tumors, pernicious anemia[1][3]
DurationShort or long term[1]
CausesHelicobacter pylori, NSAIDs, alcohol, tobacco, cocaine, viruses, parasites, autoimmune[1]
Diagnostic methodEndoscopy, upper gastrointestinal series, blood tests, stool tests[1]
Differential diagnosisMyocardial infarction, inflammation of the pancreas, gallbladder problems, peptic ulcer disease[2]
TreatmentAntacids, H2 blockers, proton pump inhibitors, antibiotics, sucralfate, bismuth subsalicylate,[1] antiemetics
Frequency~50% of people[4]
Deaths50,000 (2015)[5]

Gastritis is inflammation of the lining of the stomach.[1] It may occur as a short episode or may be of a long duration.[1] There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia).[1] Other possible symptoms include nausea and vomiting, bloating, loss of appetite and heartburn.[1][2] Complications may include stomach bleeding, stomach ulcers, and stomach tumors.[1] When due to autoimmune problems, low red blood cells due to not enough vitamin B12 may occur, a condition known as pernicious anemia.[3]

Common causes include infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs (NSAIDs).[1] When caused by H. pylori this is now termed H. pylori induced gastritis, and included as a listed disease in ICD11.[6][7]Less common causes include alcohol, smoking, cocaine, severe illness, autoimmune problems, radiation therapy and Crohn's disease.[1][8] Endoscopy, a type of X-ray known as an upper gastrointestinal series, blood tests, and stool tests may help with diagnosis.[1] The symptoms of gastritis may be a presentation of a myocardial infarction.[2] Other conditions with similar symptoms include inflammation of the pancreas, gallbladder problems, and peptic ulcer disease.[2]

Prevention is by avoiding things that cause the disease.[4] Treatment includes medications such as antacids, H2 blockers, or proton pump inhibitors.[1] During an acute attack drinking viscous lidocaine may help.[9] If gastritis is due to NSAIDs these may be stopped.[1] If H. pylori is present it may be treated with a combination of antibiotics such as amoxicillin and clarithromycin.[1] For those with pernicious anemia, vitamin B12 supplements are recommended either by mouth or by injection.[3] People are usually advised to avoid foods that bother them.[10]

Gastritis is believed to affect about half of people worldwide.[4] In 2013 there were approximately 90 million new cases of the condition.[11] As people get older the disease becomes more common.[4] It, along with a similar condition in the first part of the intestines known as duodenitis, resulted in 50,000 deaths in 2015.[5] H. pylori was first discovered in 1981 by Barry Marshall and Robin Warren.[12]

Signs and symptoms

A peptic ulcer may accompany gastritis. Endoscopic image.

Many people with gastritis experience no symptoms at all. However, upper central abdominal pain is the most common symptom; the pain may be dull, vague, burning, aching, gnawing, sore, or sharp.[13] Pain is usually located in the upper central portion of the abdomen,[14] but it may occur anywhere from the upper left portion of the abdomen around to the back.

Other signs and symptoms may include the following:

  • Nausea
  • Vomiting (may be clear, green or yellow, blood-streaked or completely bloody depending on the severity of the stomach inflammation)
  • Belching (does not usually relieve stomach pain if present)
  • Bloating
  • Early satiety[13]
  • Loss of appetite
  • Unexplained weight loss

Causes

There are two categories of gastritis depending on the cause of the disease. There is erosive gastritis, for which the common causes are stress, alcohol, some drugs, such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), and Crohn's disease. And, there is non-erosive gastritis, for which the most common cause is a Helicobacter pylori infection. [15][1]

Helicobacter pylori

Helicobacter pylori colonizes the stomachs of more than half of the world's population, and the infection continues to play a key role in the pathogenesis of a number of gastroduodenal diseases. Colonization of the gastric mucosa with Helicobacter pylori results in the development of chronic gastritis in infected individuals and, in a subset of patients, chronic gastritis progresses to complications (e.g., ulcer disease, stomach cancers, and some distinct extragastric disorders).[16] Gastritis caused by H. pylori infection is termed H. pylori induced gastritis, and listed as a disease in ICD11.[6][7] More than 80% of individuals infected with the bacterium are asymptomatic and it has been postulated that it may play an important role in the natural stomach ecology.[17]

Critical illness

Gastritis may also develop after major surgery or traumatic injury ("Cushing ulcer"), burns ("Curling ulcer"), or severe infections. Gastritis may also occur in those who have had weight loss surgery resulting in the banding or reconstruction of the digestive tract.[citation needed]

Diet

Evidence does not support a role for specific foods, including spicy foods and coffee, in the development of peptic ulcers.[18] People are usually advised to avoid foods that bother them.[10] There is little specific advice on diet published by authoritative sources. The website of the National Health Service of the United Kingdom advises "avoiding foods that can irritate the stomach, such as spicy, acidic or fried foods", and suggests that "you may want to talk to a GP about this".[19]

Pathophysiology

Acute

Early acute superficial gastritis: Marked neutrophilic infiltrates appear in the mucous neck region and lamina with a pit microabscess. This case was caused by Helicobacter pylori.

Acute erosive gastritis typically involves discrete foci of surface necrosis due to damage to mucosal defenses.[20] NSAIDs inhibit cyclooxygenase-1, or COX-1, an enzyme responsible for the biosynthesis of eicosanoids in the stomach, which increases the possibility of peptic ulcers forming.[21][22][23] Also, NSAIDs, such as aspirin, reduce a substance that protects the stomach called prostaglandin. These drugs used in a short period are not typically dangerous. However, regular use can lead to gastritis.[24] Additionally, severe physiologic stress from sepsis, hypoxia, trauma, or surgery is also a common etiology for acute erosive gastritis, resulting in "stress ulcers". This form of gastritis can occur in more than 5% of hospitalized patients.[citation needed]

Also, alcohol consumption does not cause chronic gastritis. It does, however, erode the mucosal lining of the stomach; low doses of alcohol stimulate hydrochloric acid secretion. High doses of alcohol do not stimulate secretion of acid.[25]

Chronic

Chronic gastritis refers to a wide range of problems of the gastric tissues.[20] The immune system makes proteins and antibodies that fight infections in the body to maintain a homeostatic condition. In some disorders the body targets the stomach as if it were a foreign protein or pathogen; it makes antibodies against, severely damages, and may even destroy the stomach or its lining.[24] In some cases bile, normally used to aid digestion in the small intestine, will enter through the pyloric valve of the stomach if it has been removed during surgery or does not work properly, also leading to gastritis. Gastritis may also be caused by other medical conditions, including HIV/AIDS, Crohn's disease, certain connective tissue disorders, and liver or kidney failure. Since 1992, chronic gastritis lesions are classified according to the Sydney system.[26]

Metaplasia

Mucous gland metaplasia, the reversible replacement of differentiated cells, occurs in the setting of severe damage of the gastric glands, which then waste away (atrophic gastritis) and are progressively replaced by mucous glands. Gastric ulcers may develop; it is unclear if they are the causes or the consequences. Intestinal metaplasia typically begins in response to chronic mucosal injury in the antrum and may extend to the body. Gastric mucosa cells change to resemble intestinal mucosa and may even assume absorptive characteristics. Intestinal metaplasia is classified histologically as complete or incomplete. With complete metaplasia, gastric mucosa is completely transformed into small-bowel mucosa, both histologically and functionally, with the ability to absorb nutrients and secrete peptides. In incomplete metaplasia, the epithelium assumes a histologic appearance closer to that of the large intestine and frequently exhibits dysplasia.[20]

Diagnosis

Updated Sydney System for visual classification of gastritis on histopathology.

Often, a diagnosis can be made based on patients' description of their symptoms. Other methods which may be used to verify gastritis include:

  • Blood tests:
  • Urinalysis
  • Stool sample, to look for blood in the stool
  • X-rays
  • Endoscopy, to check for stomach lining inflammation and mucous erosion
  • Stomach biopsy, to test for gastritis and other conditions[27]

The OLGA staging frame of chronic gastritis on histopathology. Atrophy is scored as the percentage of atrophic glands and scored on a four-tiered scale. No atrophy (0%) = score 0; mild atrophy (1–30%) = score 1; moderate atrophy (31–60%) = score 2; severe atrophy (>60%) = score 3. These scores (0–3) are used in the OLGA staging assessment in each 10 compartment:[28]

Corpus
No atrophy
(score 0)		 Mild atrophy
(score 1)		 Moderate atrophy
(score 2)		 Severe atrophy
(score 3)
Antrum
(including
incisura
angularis)
No atrophy (score 0) Stage 0 Stage I Stage II Stage II
Mild atrophy (score 1) Stage I Stage I Stage II Stage III
Moderate atrophy (score 2) Stage II Stage II Stage III Stage IV
Severe atrophy (score 3) Stage III Stage III Stage IV Stage IV

Treatment

Antacids are a common treatment for mild to medium gastritis.[29] When antacids do not provide enough relief, medications such as H2 blockers and proton-pump inhibitors that help reduce the amount of acid are often prescribed.[29][30]

Cytoprotective agents are designed to help protect the tissues that line the stomach and small intestine.[31] They include the medications sucralfate and misoprostol. If NSAIDs are being taken regularly, one of these medications to protect the stomach may also be taken. Another cytoprotective agent is bismuth subsalicylate.[32]

Several regimens are used to treat H. pylori infection. Most use a combination of two antibiotics and a proton pump inhibitor. Sometimes bismuth is added to the regimen.

History

In 1,000 A.D, Avicenna first gave the description of stomach cancer. In 1728, German physician Georg Ernst Stahl first coined the term "gastritis". Italian anatomical pathologist Giovanni Battista Morgagni further described the characteristics of gastric inflammation. He described the characteristics of erosive or ulcerative gastritis and erosive gastritis. Between 1808 and 1831, French physician François-Joseph-Victor Broussais gathered information from the autopsies of dead French soldiers. He described chronic gastritis as "Gastritide" and erroneously believed that gastritis was the cause of ascites, typhoid fever, and meningitis. In 1854, Charles Handfield Jones and Wilson Fox described the microscopic changes of stomach inner lining in gastritis which existed in diffuse and segmental forms. In 1855, Baron Carl von Rokitansky first described hypertrophic gastritis. In 1859, British physician, William Brinton first described about acute, subacute, and chronic gastritis. In 1870, Samuel Fenwick noted that pernicious anemia causes glandular atrophy in gastritis. German surgeon Georg Ernst Konjetzny noticed that both gastric ulcer and gastric cancer are the results of gastric inflammation. Shields Warren and Willam A. Meissner described the intestinal metaplasia of the stomach as a feature of chronic gastritis.[33]

See also

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 "Gastritis". November 27, 2013. http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/gastritis/Pages/facts.aspx. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Rosen & Barkin's 5-Minute Emergency Medicine Consult (4 ed.). Lippincott Williams & Wilkins. 2012. p. 447. ISBN 9781451160970. https://books.google.com/books?id=3JNUG-m0650C&pg=PA447. 
  3. ↑ 3.0 3.1 3.2 Varbanova, M.; Frauenschläger, K.; Malfertheiner, P. (Dec 2014). "Chronic gastritis - an update.". Best Pract Res Clin Gastroenterol 28 (6): 1031–42. doi:10.1016/j.bpg.2014.10.005. PMID 25439069. 
  4. ↑ 4.0 4.1 4.2 4.3 Fred F. Ferri (2012). Ferri's Clinical Advisor 2013,5 Books in 1, Expert Consult - Online and Print,1: Ferri's Clinical Advisor 2013. Elsevier Health Sciences. p. 417. ISBN 9780323083737. https://books.google.com/books?id=OR3VERnvzzEC&pg=PA417. 
  5. ↑ 5.0 5.1 Wang, Haidong et al. (8 October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.". The Lancet 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. ISSN 0140-6736. PMID 27733281. 
  6. ↑ 6.0 6.1 "Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report". Gut 71 (9): 1724–1762. August 2022. doi:10.1136/gutjnl-2022-327745. PMID 35944925. 
  7. ↑ 7.0 7.1 "ICD-11 for Mortality and Morbidity Statistics". https://icd.who.int/browse11/l-m/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f88597691. 
  8. ↑ Hauser, Stephen (2014). Mayo Clinic Gastroenterology and Hepatology Board Review. Oxford University Press. pp. 49. ISBN 9780199373338. https://books.google.com/books?id=1bITBAAAQBAJ&pg=PA49. 
  9. ↑ Adams (2012). "32". Emergency Medicine: Clinical Essentials. Elsevier Health Sciences. ISBN 9781455733941. https://books.google.com/books?id=rpoH-KYE93IC&pg=PP1314. 
  10. ↑ 10.0 10.1 Oxford handbook of nutrition and dietetics (2nd ed.). Oxford: Oxford University Press, USA. 2012. p. 571. ISBN 9780199585823. https://books.google.com/books?id=8DugwipyfHgC&pg=PA571. 
  11. ↑ Vos, Theo et al. (22 August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.". The Lancet 386 (9995): 743–800. doi:10.1016/s0140-6736(15)60692-4. ISSN 0140-6736. PMID 26063472. 
  12. ↑ Wang, Andrew Y.; Peura, David A. (October 2011). "The prevalence and incidence of Helicobacter pylori-associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world". Gastrointestinal Endoscopy Clinics of North America 21 (4): 613–635. doi:10.1016/j.giec.2011.07.011. ISSN 1558-1950. PMID 21944414. https://pubmed.ncbi.nlm.nih.gov/21944414/. 
  13. ↑ 13.0 13.1 "Gastritis Symptoms". eMedicineHealth. 2008. http://www.emedicinehealth.com/gastritis/article_em.htm. 
  14. ↑ "Gastritis". National Digestive Diseases Information Clearinghouse (National Institute of Diabetes and Digestive and Kidney Diseases). December 2004. http://digestive.niddk.nih.gov/ddiseases/pubs/gastritis/. 
  15. ↑ Vakil, Nimish (June 2021). "Gastritis - Digestive Disorders" (in en). Merck & Co.. https://www.msdmanuals.com/home/digestive-disorders/gastritis-and-peptic-ulcer-disease/gastritis. 
  16. ↑ Kandulski, Arne; Selgrad, Michael; Malfertheiner, P. (2008-08-01). "Helicobacter pylori infection: a clinical overview". Digestive and Liver Disease 40 (8): 619–626. doi:10.1016/j.dld.2008.02.026. PMID 18396114. 
  17. ↑ Blaser, M. J. (2006). "Who are we? Indigenous microbes and the ecology of human diseases". EMBO Reports 7 (10): 956–60. doi:10.1038/sj.embor.7400812. PMID 17016449. PMC 1618379. http://www.nature.com/embor/journal/v7/n10/pdf/7400812.pdf. 
  18. ↑ Rubin's pathology : clinicopathologic foundations of medicine (Sixth ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2012. p. 623. ISBN 9781605479682. https://books.google.com/books?id=wb2TzY9AgJ0C&pg=PA623. 
  19. ↑ "Gastritis: Things you can do to ease gastritis". 2019-05-20. https://www.nhs.uk/conditions/gastritis. 
  20. ↑ 20.0 20.1 20.2 Vakil, Nimish (January 2007). "Gastritis". Merck & Co.. http://www.merck.com/mmpe/sec02/ch013/ch013c.html. 
  21. ↑ Dajani, Esam Z.; Islam, K. (2008-08-01). "Cardiovascular and gastrointestinal toxicity of selective cyclo-oxygenase-2 inhibitors in man". Journal of Physiology and Pharmacology 59 (Suppl 2): 117–133. ISSN 1899-1505. OCLC 165902827. PMID 18812633. http://www.jpp.krakow.pl/journal/archive/0808_s2/pdf/117_0808_s2_article.pdf. [yes|permanent dead link|dead link}}]
  22. ↑ Yokoyama, Chieko; Tanabe, Tadashi (1989-12-15). "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme". Biochemical and Biophysical Research Communications 165 (2): 888–94. doi:10.1016/S0006-291X(89)80049-X. ISSN 0006-291X. OCLC 1532958. PMID 2512924. 
  23. ↑ Funk, Colin D.; Funk, Lena B.; Kennedy, Matthew E.; Pong, Amy S.; Fitzgerald, Garret A. (1991-06-01). "Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment". The FASEB Journal 5 (9): 2304–2312. doi:10.1096/fasebj.5.9.1907252. ISSN 0892-6638. OCLC 1096896944. PMID 1907252. 
  24. ↑ 24.0 24.1 Siegelbaum, Jackson (2019-08-23). "GI Health Resources > Gastritis". https://www.gicare.com/gi-health-resources/gastritis/. 
  25. ↑ Wolff, G (1989). "[Effect of alcohol on the stomach]" (in de). Gastroenterologisches Journal 49 (2): 45–49. ISSN 0863-1743. PMID 2679657. 
  26. ↑ Mayo Clinic Staff (April 13, 2007). "Gastritis". MayoClinic. http://www.mayoclinic.com/health/gastritis/DS00488/DSECTION=causes. 
  27. ↑ "Exams and Tests". eMedicinHealth. 2008. http://www.emedicinehealth.com/gastritis/page3_em.htm. 
  28. ↑ Carrasco G, Corvalan AH (2013). "Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer.". Gastroenterol Res Pract 2013: 393015. doi:10.1155/2013/393015. PMID 23983680.   This article incorporates text available under the CC BY 3.0 license.
  29. ↑ 29.0 29.1 Zajac, P; Holbrook, A; Super, ME; Vogt, M (March–April 2013). "An overview: Current clinical guidelines for the evaluation, diagnosis, treatment, and management of dyspepsia". Osteopathic Family Physician 5 (2): 79–85. doi:10.1016/j.osfp.2012.10.005. 
  30. ↑ "Guide to the use of proton pump inhibitors in adult patients". Drugs 68 (7): 925–47. 2008. doi:10.2165/00003495-200868070-00004. PMID 18457460. 
  31. ↑ Fashner, J; Gitu, AC (15 February 2015). "Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection.". American Family Physician 91 (4): 236–42. PMID 25955624. 
  32. ↑ "Gastritis". https://www.lecturio.com/concepts/gastritis/. 
  33. ↑ Gyula, Mozsik (16 January 2013). "Chapter 1: Diagnosis of Gastritis – Review from Early Pathological Evaluation to Present Day Management". Current Topics in gastritis. University of Pécs. pp. 1–19. ISBN 978-953-51-0907-5. https://cdn.intechopen.com/pdfs/41544.pdf. Retrieved 10 July 2018. 

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