Medicine:Psychogenic amnesia

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Short description: Human memory disorder
Psychogenic amnesia
Other namesDissociative amnesia
SpecialtyPsychiatry
SymptomsReported memory loss[1]

Psychogenic amnesia or dissociative amnesia is a memory disorder characterized by sudden retrograde episodic memory loss, said to occur for a period of time ranging from hours to years to decades.[2] More recently, "dissociative amnesia" has been defined as a dissociative disorder "characterized by retrospectively reported memory gaps. These gaps involve an inability to recall personal information, usually of a traumatic or stressful nature."[1] In a change from the DSM-IV to the DSM-5, dissociative fugue is now subsumed under dissociative amnesia.[3]

The atypical clinical syndrome of the memory disorder (as opposed to organic amnesia) is that a person with psychogenic amnesia is profoundly unable to remember personal information about themselves; there is a lack of conscious self-knowledge which affects even simple self-knowledge, such as who they are.[4] Psychogenic amnesia is distinguished from organic amnesia in that it is supposed to result from a nonorganic cause: no structural brain damage or brain lesion should be evident but some form of psychological stress should precipitate the amnesia,[5] however psychogenic amnesia as a memory disorder is controversial.[6]

Definition

Psychogenic amnesia is the presence of retrograde amnesia (the inability to retrieve stored memories leading up to the onset of amnesia), and an absence of anterograde amnesia (the inability to form new long term memories).[7][8][9] Access to episodic memory can be impeded,[2] while the degree of impairment to short term memory, semantic memory and procedural memory is thought to vary among cases.[4] If other memory processes are affected, they are usually much less severely affected than retrograde autobiographical memory, which is taken as the hallmark of psychogenic amnesia.[4] However the wide variability of memory impairment among cases of psychogenic amnesia raises questions as to its true neuropsychological criteria, as despite intense study of a wide range of cases there is little consensus of which memory deficits are specific to psychogenic amnesia.[6]

Past literature[4] has suggested psychogenic amnesia can be 'situation-specific' or 'global-transient', the former referring to memory loss for a particular incident, and the latter relating to large retrograde amnesic gaps of up to many years in personal identity.[4][10] The most commonly cited examples of global-transient psychogenic amnesia are 'fugue states', of which there is a sudden retrograde loss of autobiographical memory resulting in impairment of personal identity and usually accompanied by a period of wandering.[6] Suspected cases of psychogenic amnesia have been heavily reported throughout the literature since 1935 where it was reported by Abeles and Schilder.[11] There are many clinical anecdotes of psychogenic or dissociative amnesia attributed to stressors ranging from cases of child sexual abuse[12] to soldiers returning from combat.[1][13]

Cause

Neurological cause of psychogenic amnesia is controversial.[4][6] Even in cases of organic amnesia, where there is lesion or structural damage to the brain, caution must still be taken in defining causation, as only damage to areas of the brain crucial to memory processing is possible to result in memory impairment.[6] Organic causes of amnesia can be difficult to detect, and often both organic cause and psychological triggers can be entangled.[14] Failure to find an organic cause may result in the diagnosis that the amnesia is psychological,[15] however it is possible that some organic causes may fall below a threshold of detection, while other neurological ails are thought to be unequivocally organic (such as a migraine) even though no functional damage is evident.[6] Possible malingering must also be taken into account.[16] Some researchers[15] have cautioned against psychogenic amnesia becoming a "wastebasket"[15] diagnosis when organic amnesia is not apparent. Other researchers[16] have hastened to defend the notion of psychogenic amnesia and its right not to be dismissed as a clinical disorder. Diagnoses of psychogenic amnesia have dropped since agreement in the field of transient global amnesia, suggesting some over diagnosis at least.[15] Speculation also exists about psychogenic amnesia due to its similarities with 'pure retrograde amnesia', as both share similar retrograde loss of memory.[6] Also, although no functional damage or brain lesions are evident in the case of pure retrograde amnesia, unlike psychogenic amnesia it is not thought that purely psychological or 'psychogenic triggers' are relevant to pure retrograde amnesia.[6] Psychological triggers such as emotional stress are common in everyday life, yet pure retrograde amnesia is considered very rare.[6] Also the potential for organic damage to fall below threshold of being identified does not necessarily mean it is not present, and it is highly likely that both psychological factors and organic cause exist in pure retrograde amnesia.[6]

Comparison with organic amnesia

Psychogenic amnesia is supposed to differ from organic amnesia in a number of ways; one being that unlike organic amnesia, psychogenic amnesia is thought to occur when no structural damage to the brain or brain lesion is evident.[17] Psychological triggers are instead considered as preceding psychogenic amnesia,[16] and indeed many anecdotal case studies which are cited as evidence of psychogenic amnesia hail from traumatic experiences[12] such as World War II.[13] As aforementioned however, an etiology of psychogenic amnesia is controversial[4] as causation is not always clear[17] (see above paragraph), and both elements of psychological stress and organic amnesia may be present among cases.[6] Often, but not necessarily, a premorbid history of psychiatric illness such as depression is thought to be present in conjunction to triggers of psychological stress.[4] Lack of psychological evidence precipitating amnesia doesn't mean there isn't any, for example trauma during childhood has even been cited as triggering amnesia later in life,[2] but such an argument runs the risk of psychogenic amnesia becoming an umbrella term for any amnesia of which there is no apparent organic cause.[15] Due to organic amnesia often being difficult to detect,[17] defining between organic and psychogenic amnesia is not easy[16] and often context of precipitating experiences are considered (for example, if there has been drug abuse) as well as the symptomology the patient presents with.[17] Psychogenic amnesia is supposed to differ from organic amnesia qualitatively[4] in that retrograde loss of autobiographical memory while semantic memory remains intact is said to be specific of psychogenic amnesia.[2][4] Another difference that has been cited between organic and psychogenic amnesia is the temporal gradient of retrograde loss of autobiographical memory.[4] The temporal gradient of loss in most cases of organic amnesia is said to be steepest at its most recent premorbid period, whereas for psychogenic amnesia the temporal gradient of retrograde autobiographical memory loss is said to be quite consistently flat.[4] Although there is much literature on psychogenic amnesia as dissimilar to organic amnesia, the distinction between neurological and psychological features is often difficult to discern and remains controversial.[18][19][20]

Diagnosis

Functional assessment of brain activity can be assessed for psychogenic amnesia using imaging techniques such as fMRI, PET and EEG, in accordance with clinical data.[6] Some research has suggested that organic and psychogenic amnesia to some extent share the involvement of the same structures of the temporo-frontal region in the brain.[7] It has been suggested that deficits in episodic memory may be attributable to dysfunction in the limbic system,[21] while self-identity deficits have been suggested as attributable to functional changes related to the posterior parietal cortex.[2] To reiterate however, care must be taken when attempting to define causation as only ad hoc reasoning about the aetiology of psychogenic amnesia is possible, which means cause and consequence can be infeasible to untangle.[15]

Treatments

Because psychogenic amnesia is defined by its lack of physical damage to the brain,[15] treatment by physical methods is difficult.[6] Nonetheless, distinguishing between organic and dissociative memory loss has been described as an essential first-step in effective treatments.[1] Treatments in the past have attempted to alleve psychogenic amnesia by treating the mind itself, as guided by theories which range from notions such as 'betrayal theory' to account for memory loss attributed to protracted abuse by caregivers[22] to the amnesia as a form of self-punishment in a Freudian sense, with the obliteration of personal identity as an alternative to suicide.[23]

Treatment attempts often have revolved around trying to discover what traumatic event had caused the amnesia, and drugs such as intravenously administered barbiturates (often thought of as 'truth serum') were popular as treatment for psychogenic amnesia during World War II; benzodiazepines may have been substituted later.[13] 'Truth serum' drugs were thought to work by making a painful memory more tolerable when expressed through relieving the strength of an emotion attached to a memory.[24] Under the influence of these 'truth' drugs the patient would more readily talk about what had occurred to them.[13] However, information elicited from patients under the influence of drugs such as barbiturates would be a mixture of truth and fantasy, and was thus not regarded as scientific in gathering accurate evidence for past events.[13] Often treatment was aimed at treating the patient as a whole, and probably varied in practice in different places.[13] Hypnosis was also popular as a means for gaining information from people about their past experiences, but like 'truth' drugs really only served to lower the threshold of suggestibility so that the patient would speak easily but not necessarily truthfully.[25] If no motive for the amnesia was immediately apparent, deeper motives were usually sought by questioning the patient more intensely, often in conjunction with hypnosis and 'truth' drugs.[23] In many cases, however, patients were found to spontaneously recover from their amnesia on their own accord so no treatment was required.[13][23]

In popular culture

Psychogenic amnesia is a common fictional plot device in many films, books and other media. Examples include William Shakespeare's King Lear, who experienced amnesia and madness following a betrayal by his daughters;[26] and the title character Nina in Nicolas Dalayrac's 1786 opera.[26]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "Dissociative Amnesia and DSM-IV-TR Cluster C Personality Traits". Psychiatry (Edgmont) 3 (1): 51–5. January 2006. PMID 21103150. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Arzy, S.; Collette, S.; Wissmeyere, M.; Lazeyras, F.; Kaplan, P. W.; Blank, O. (2001). "Psychogenic amnesia and self-identity: a multimodal functional investigation". European Journal of Neurology 18 (12): 1422–1425. doi:10.1111/j.1468-1331.2011.03423.x. PMID 21554495. http://infoscience.epfl.ch/record/170666. 
  3. ↑ American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 Serraa, L.; Faddaa, L.; Buccionea, I.; Caltagironea, C.; Carlesimoa, G. A. (2007). "Psychogenic and organic amnesia. A multidimensional assessment of clinical, neuroradiological, neuropsychological and psychopathological features.". Behavioural Neurology 18 (1): 53–64. doi:10.1155/2007/193140. PMID 17297220. 
  5. ↑ Markowitsch, H. J.; Fink, G. R.; Thone, A.; Kessler, J.; Heiss, W-D. (1997). "A PET study of persistent psycogenic amnesia covering the whole life span". Cognitive Neuropsychiatry 2 (2): 135–158. doi:10.1080/135468097396379. PMID 25420201. 
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 Lucchelli, F.; Spinnler, H. (2003). "The "psychogenic" versus "organic" conundrum of pure retrograde amnesia: Is it still worth pursuing?". Cortex 38 (4): 665–669. doi:10.1016/s0010-9452(08)70033-9. PMID 12465679. 
  7. ↑ 7.0 7.1 Markowitsch HJ (2003). "Psychogenic amnesia". NeuroImage 20 Suppl 1: S132–8. doi:10.1016/j.neuroimage.2003.09.010. PMID 14597306. 
  8. ↑ "Functional anatomical study of psychogenic amnesia". Psychiatry Res 99 (1): 43–57. 2000. doi:10.1016/S0925-4927(00)00057-3. PMID 10891648. 
  9. ↑ Mackenzie Ross S (2000). "Profound retrograde amnesia following mild head injury: organic or functional?". Cortex 36 (4): 521–37. doi:10.1016/S0010-9452(08)70536-7. PMID 11059453. 
  10. ↑ Kopelman MD (2002). "Disorders of memory". Brain 125 (Pt 10): 2152–90. doi:10.1093/brain/awf229. PMID 12244076. 
  11. ↑ Abeles, M.; Schilder, P. (1935). "Psychogenic loss of personal identity". Archives of Neurology and Psychiatry 34 (3): 587–604. doi:10.1001/archneurpsyc.1935.02250210108008. 
  12. ↑ 12.0 12.1 Arrigo, J. M.; Pezdek, K. (1997). "Lessons from the study of psychogenic amnesia". Current Directions in Psychological Science 6 (5): 148–152. doi:10.1111/1467-8721.ep10772916. 
  13. ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 Sargant, W.; Slater, E. (1941). "Amnesic syndromes in war". Journal of the Royal Society of Medicine 34 (12): 757–764. doi:10.1177/003591574103401202. 
  14. ↑ Kopelman, M. D.; Christensen, H.; Puffett, A.; Stanhope, N. (1994). "The great escape: A neuropsychological study of psychogenic amnesia". Neuropsychologia 32 (6): 675–691. doi:10.1016/0028-3932(94)90028-0. PMID 8084423. 
  15. ↑ 15.0 15.1 15.2 15.3 15.4 15.5 15.6 Renzi, E. D.; Lucchelli, F.; Muggia, S.; Spinnler, H. (1997). "Is memory loss without anatomical damage tantamount to a psychogenic deficit? The case of pure retrograde amnesia". Neuropsychologia 35 (6): 781–794. doi:10.1016/s0028-3932(97)00018-3. PMID 9204485. 
  16. ↑ 16.0 16.1 16.2 16.3 Kopelman, M. D. (2000). "Focal retrograde amnesia and the attribution of causality: An exceptionally critical review". Cognitive Neuropsychology 17 (7): 585–621. doi:10.1080/026432900750002172. PMID 20945196. 
  17. ↑ 17.0 17.1 17.2 17.3 Kopelman, M. D.; Christensen, H.; Puffett, A.; Stanhope, N. (1994). "The great escape: A neuropsychological study of psychogenic amnesia". Neuropsychologia 32 (6): 675–691. doi:10.1016/0028-3932(94)90028-0. PMID 8084423. 
  18. ↑ De Renzi, E.; Lucchelli, F.; Muggia, S.; Spinnler, H. (1995). "Persistent retrograde amnesia following a minor trauma". Cortex 31 (3): 531–542. doi:10.1016/s0010-9452(13)80064-0. PMID 8536480. 
  19. ↑ Lucchelli, F.; Muggia, S.; Spinnler, H. (1995). "The "Petites Madeleines" phenomenon in two amnesic patients. Sudden recovery of forgotten memories". Brain 118: 167–183. doi:10.1093/brain/118.1.167. PMID 7895003. 
  20. ↑ Campodonico, J. R.; Rediess, S. (1996). "Dissociation of implicit and explicit knowledge in a case of psychogenic retrograde amnesia". Journal of the International Neuropsychological Society 2 (19): 191–203. doi:10.1017/s1355617700001004. PMID 9375200. 
  21. ↑ "Functional MR imaging of psychogenic amnesia: a case report". Korean J Radiol 6 (3): 196–9. 2005. doi:10.3348/kjr.2005.6.3.196. PMID 16145296. 
  22. ↑ Freyd, J. (1994). "Betrayal Trauma: Traumatic Amnesia as an Adaptive Response to Childhood Abuse.". Ethics & Behavior 4 (4): 307–330. doi:10.1207/s15327019eb0404_1. https://www.questia.com/read/95814385. Retrieved 2008-01-13. 
  23. ↑ 23.0 23.1 23.2 Abeles, M.; Schilder, P. (1935). "Psychogenic loss of personal identity". Archives of Neurology 34 (3): 587–604. doi:10.1001/archneurpsyc.1935.02250210108008. 
  24. ↑ Vattakatuchery, JJ; Chesterman, P (2006). "The use of abreaction to recover memories in psychogenic amnesia: A case report". Journal of Forensic Psychiatry and Psychology 17 (4): 647–653. doi:10.1080/14789940600965938. 
  25. ↑ Lynn, S. J.; Boycheva, E.; Barnes, S. (2008). "To assess or to not assess hypnotic suggestibility? That is the question". American Journal of Clinical Hypnosis 51 (2): 161–165. doi:10.1080/00029157.2008.10401658. PMID 18998383. https://semanticscholar.org/paper/6d47a573f198fbc1e86f3c6e3d4500d2ef8ccb1d. 
  26. ↑ 26.0 26.1 Goldsmith, R.E.; Cheit, R.E.; Wood, M.E. (July 2009). "Evidence of Dissociative Amnesia in Science and Literature: Culture-Bound Approaches to Trauma in Pope, Poliakoff, Parker, Boynes, and Hudson (2007)". Journal of Trauma & Dissociation 10 (3): 237–253. doi:10.1080/15299730902956572. PMID 19585333. 

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