Biology:Scyllo-inosamine 4-kinase
From HandWiki
Short description: Enzyme
| scyllo-inosamine 4-kinase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.1.65 | ||||||||
| CAS number | 37278-08-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a scyllo-inosamine 4-kinase (EC 2.7.1.65) is an enzyme that catalyzes the chemical reaction
- ATP + 1-amino-1-deoxy-scyllo-inositol [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
Thus, the two substrates of this enzyme are ATP and 1-amino-1-deoxy-scyllo-inositol, whereas its two products are ADP and 1-amino-1-deoxy-scyllo-inositol 4-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase. Other names in common use include scyllo-inosamine kinase (phosphorylating), scyllo-inosamine kinase, and ATP:inosamine phosphotransferase. This enzyme participates in streptomycin biosynthesis.
References
- Walker JB (1971). "Enzymatic reactions involved in streptomycin biosynthesis and metabolism". Lloydia 34 (4): 363–71. PMID 4376579.
- "Enzymatic synthesis of streptidine from scyllo-inosamine". Biochemistry 6 (12): 3821–9. 1967. doi:10.1021/bi00864a028. PMID 6076630.
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