Biology:CHRNA5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[1][2] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).
Function
Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[2] CHRNA5 is a candidate gene for predisposition to nicotine dependence and to lung cancer risk. [3] Polymorphisms in the CHRNA5 promoter are functionally associated with CHRNA5 transcript levels in lung tissue. [4]
Interactive pathway map
See also
References
- ↑ "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics 9 (2): 278–82. Apr 1991. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
- ↑ 2.0 2.1 "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138.
- ↑ Hung et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452(7187):633–637.
- ↑ Falvella et al. Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5. J Natl Cancer Inst. 2010;102(17):1366–1370.
Further reading
- "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol.. Reviews of Physiology, Biochemistry and Pharmacology 147: 1–46. 2003. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
- "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. 1992. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
- "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. 1992. doi:10.1073/pnas.89.5.1572. PMID 1542648. Bibcode: 1992PNAS...89.1572C.
- Raimondi E; Rubboli F; Moralli D et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664.
- Elliott KJ; Ellis SB; Berckhan KJ et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.
- "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. 1997. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.
- "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. 1997. PMID 9193799.
- "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. 1998. PMID 9655874.
- Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230.
- "Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–96. 2001. doi:10.1038/sj.bjp.0704313. PMID 11606319.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Soldà G; Boi S; Duga S et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs". Gene 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100.
External links
- CHRNA5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CHRNA5 genome location and CHRNA5 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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