Biology:Adenosylcobinamide-GDP ribazoletransferase
From HandWiki
| Adenosylcobinamide-GDP ribazoletransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.8.26 | ||||||||
| CAS number | 137672-85-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- (1) adenosylcobinamide-GDP + alpha-ribazole [math]\displaystyle{ \rightleftharpoons }[/math] GMP + adenosylcobalamin
- (2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] GMP + adenosylcobalamin 5'-phosphate
This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.
See also
References
- ↑ "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes". Proceedings of the National Academy of Sciences of the United States of America 96 (21): 11798–803. October 1999. doi:10.1073/pnas.96.21.11798. PMID 10518530. Bibcode: 1999PNAS...9611798M.
- ↑ "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports 19 (4): 390–412. August 2002. doi:10.1039/b108967f. PMID 12195810.
- ↑ "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase". Journal of Bacteriology 173 (19): 6066–73. October 1991. doi:10.1128/jb.173.19.6066-6073.1991. PMID 1917841.
External links
- Adenosylcobinamide-GDP+ribazoletransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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