Biology:GRIN1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.[1][2]
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing demonstrated in human, mouse and rat.[3][4][5][6] Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.[2]
See also
References
- ↑ "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science 256 (5060): 1217–1221. May 1992. doi:10.1126/science.256.5060.1217. PMID 1350383. Bibcode: 1992Sci...256.1217M.
- ↑ 2.0 2.1 "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2902.
- ↑ "Control of Long-Term Synaptic Potentiation and Learning by Alternative Splicing of the NMDA Receptor Subunit GluN1". Cell Reports 29 (13): 4285–4294.e5. December 2019. doi:10.1016/j.celrep.2019.11.087. PMID 31875540.
- ↑ "N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility". Proceedings of the National Academy of Sciences of the United States of America 116 (42): 21207–21212. October 2019. doi:10.1073/pnas.1905721116. PMID 31570583. Bibcode: 2019PNAS..11621207L.
- ↑ "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences 78 (14): 5605–5630. July 2021. doi:10.1007/s00018-021-03865-z. PMID 34100982.
- ↑ "Age and visual experience-dependent expression of NMDAR1 splice variants in rat retina". Neurochemical Research 36 (8): 1417–1425. August 2011. doi:10.1007/s11064-011-0467-5. PMID 21499738.
Further reading
- "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". The Journal of Neuroscience 18 (6): 2017–2027. March 1998. doi:10.1523/JNEUROSCI.18-06-02017.1998. PMID 9482789.
- "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology 19 (4–5): 683–688. 1998. PMID 9745929.
- "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental Brain Research 123 (1–2): 52–59. November 1998. doi:10.1007/s002210050544. PMID 9835392.
- "The glutamate receptor ion channels". Pharmacological Reviews 51 (1): 7–61. March 1999. PMID 10049997.
- "HIV tat and neurotoxicity". Microbes and Infection 8 (5): 1347–1357. April 2006. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
- "Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1)". Gene 159 (2): 219–223. July 1995. doi:10.1016/0378-1119(95)00044-7. PMID 7622053.
- "Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor". The Journal of Biological Chemistry 268 (5): 3728–3733. February 1993. doi:10.1016/S0021-9258(18)53754-6. PMID 7679115.
- "Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 2174–2178. March 1993. doi:10.1073/pnas.90.6.2174. PMID 7681588. Bibcode: 1993PNAS...90.2174Y.
- "Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain". Proceedings of the National Academy of Sciences of the United States of America 90 (11): 5057–5061. June 1993. doi:10.1073/pnas.90.11.5057. PMID 7685113. Bibcode: 1993PNAS...90.5057P.
- "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Annals of Neurology 37 (3): 373–380. March 1995. doi:10.1002/ana.410370314. PMID 7695237.
- "Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits". Gene 147 (2): 303–304. September 1994. doi:10.1016/0378-1119(94)90089-2. PMID 7926821.
- "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature 368 (6467): 144–147. March 1994. doi:10.1038/368144a0. PMID 8139656. Bibcode: 1994Natur.368..144S.
- "Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain". Nature 364 (6432): 70–73. July 1993. doi:10.1038/364070a0. PMID 8316301. Bibcode: 1993Natur.364...70T.
- "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene 131 (2): 293–298. September 1993. doi:10.1016/0378-1119(93)90309-Q. PMID 8406025.
- "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics 17 (1): 237–239. July 1993. doi:10.1006/geno.1993.1311. PMID 8406459.
- "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". The European Journal of Neuroscience 7 (11): 2285–2293. November 1995. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.
- "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration 4 (3): 315–321. September 1995. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
- "Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit". Cell 84 (5): 745–755. March 1996. doi:10.1016/S0092-8674(00)81052-1. PMID 8625412.
- "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS 10 (5): 463–468. May 1996. doi:10.1097/00002030-199605000-00003. PMID 8724036.
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