Biology:GRIA1
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.[1][2]
Function
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1–4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.[3]
GRIA1 (GluR1) is centrally involved in synaptic plasticity. Expression of the GluR1 gene is significantly reduced in the human frontal cortex with increasing age.[4]
Interactions
GRIA1 has been shown to interact with:
See also
- AMPA receptor
References
- ↑ "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A 88 (17): 7557–7561. October 1991. doi:10.1073/pnas.88.17.7557. PMID 1652753. Bibcode: 1991PNAS...88.7557P.
- ↑ "Chromosomal localization of human glutamate receptor genes". J Neurosci 12 (7): 2555–2562. July 1992. doi:10.1523/JNEUROSCI.12-07-02555.1992. PMID 1319477.
- ↑ "Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890.
- ↑ "Gene regulation and DNA damage in the ageing human brain". Nature 429 (6994): 883–891. June 2004. doi:10.1038/nature02661. PMID 15190254. Bibcode: 2004Natur.429..883L.
- ↑ "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. 278 (45): 44745–44752. November 2003. doi:10.1074/jbc.M303576200. PMID 12933808.
- ↑ "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". J. Biol. Chem. 273 (31): 19518–19524. July 1998. doi:10.1074/jbc.273.31.19518. PMID 9677374.
- ↑ "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway". J. Neurosci. 21 (19): 7506–7516. October 2001. doi:10.1523/JNEUROSCI.21-19-07506.2001. PMID 11567040.
- ↑ "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". J. Neurosci. 20 (21): 7932–7940. November 2000. doi:10.1523/JNEUROSCI.20-21-07932.2000. PMID 11050113.
- ↑ "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. January 2003. doi:10.1016/s0169-328x(02)00561-2. PMID 12573530.
Further reading
- "Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1443–1447. 1992. doi:10.1073/pnas.89.4.1443. PMID 1311100. Bibcode: 1992PNAS...89.1443S.
- "The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5.". DNA Seq. 2 (4): 211–218. 1992. doi:10.3109/10425179209020805. PMID 1320959.
- "Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1376–1380. 1995. doi:10.1073/pnas.92.5.1376. PMID 7877986. Bibcode: 1995PNAS...92.1376Y.
- "AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.". NeuroReport 5 (11): 1325–1328. 1994. doi:10.1097/00001756-199406270-00007. PMID 7919190.
- "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–11682. 1994. doi:10.1016/S0021-9258(17)32623-6. PMID 8163463.
- "Expression of alternatively-spliced glutamate receptors in human hippocampus.". Eur. J. Pharmacol. 244 (1): 89–92. 1993. doi:10.1016/0922-4106(93)90062-E. PMID 8420792.
- "Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.". Neuron 16 (6): 1179–1188. 1996. doi:10.1016/S0896-6273(00)80144-0. PMID 8663994.
- "Homer: a protein that selectively binds metabotropic glutamate receptors.". Nature 386 (6622): 284–288. 1997. doi:10.1038/386284a0. PMID 9069287. Bibcode: 1997Natur.386..284B.
- "Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor.". J. Biol. Chem. 272 (52): 32727–32730. 1998. doi:10.1074/jbc.272.52.32727. PMID 9407043.
- "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–497. 1998. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.
- "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.". J. Biol. Chem. 273 (31): 19518–19524. 1998. doi:10.1074/jbc.273.31.19518. PMID 9677374.
- "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–716. 1998. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
- "Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb.". J. Comp. Neurol. 405 (2): 233–246. 1999. doi:10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A. PMID 10023812.
- "Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.". J. Biol. Chem. 274 (24): 16907–16916. 1999. doi:10.1074/jbc.274.24.16907. PMID 10358037.
- "Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.". Science 284 (5421): 1811–1816. 1999. doi:10.1126/science.284.5421.1811. PMID 10364548.
- "Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors.". J. Neurochem. 73 (3): 942–948. 1999. doi:10.1046/j.1471-4159.1999.0730942.x. PMID 10461883.
- "Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex.". Brain Res. 861 (1): 37–44. 2000. doi:10.1016/S0006-8993(00)01952-1. PMID 10751563.
External links
- GRIA1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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