Biology:Bone morphogenetic protein 5
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Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[1][2][3]
The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[3]
References
- ↑ "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. Nov 1992. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
- ↑ "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience 2: 12. Mar 2003. doi:10.1186/1471-2202-2-12. PMID 11580864.
- ↑ 3.0 3.1 "Entrez Gene: BMP5 bone morphogenetic protein 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653.
External links
- Human BMP5 genome location and BMP5 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America 87 (24): 9843–7. Dec 1990. doi:10.1073/pnas.87.24.9843. PMID 2263636. Bibcode: 1990PNAS...87.9843C.
- "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications 221 (3): 768–72. Apr 1996. doi:10.1006/bbrc.1996.0671. PMID 8630036.
- "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science 40 (2): 296–311. Feb 1999. PMID 9950587.
- "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International 51 (8): 643–8. Aug 2001. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221.
- "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology 16 (4): 1013–9. Oct 2001. PMID 11642720.
- "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics 107 (1): 48–51. Jan 2002. doi:10.1002/ajmg.10083. PMID 11807867.
- "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science 115 (Pt 4): 753–60. Feb 2002. doi:10.1242/jcs.115.4.753. PMID 11865031.
- "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate 51 (3): 189–200. May 2002. doi:10.1002/pros.10087. PMID 11967953.
- "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision 8: 241–50. Jul 2002. PMID 12131877.
- "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development 131 (1): 229–40. Jan 2004. doi:10.1242/dev.00901. PMID 14660436.
- "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International 28 (10): 675–82. 2005. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325.
- "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal 46 (3): 389–96. Jun 2005. PMID 15861517.
- "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy 8 (3): R58. 2006. doi:10.1186/ar1923. PMID 16542506.
- "Extreme context specificity in differential allelic expression". Human Molecular Genetics 16 (5): 537–46. Mar 2007. doi:10.1093/hmg/ddl488. PMID 17220169.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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