Biology:Bone morphogenetic protein 3

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.[2][3]

References

  1. ↑ "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=651. 
  2. ↑ "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease 18 (6): 549–61. June 2016. doi:10.1111/codi.13336. PMID 26998585. 
  3. ↑ Kormi, Seyed Mohammad Amin; Ardehkhani, Shima; Kerachian, Mohammad Amin (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer 6 (2): 63–68. doi:10.2217/crc-2017-0007. 

External links

Further reading

  • "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics 6 (3): 505–20. March 1990. doi:10.1016/0888-7543(90)90480-I. PMID 1970330. 
  • "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics 9 (2): 283–9. February 1991. doi:10.1016/0888-7543(91)90254-C. PMID 2004778. 
  • "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry 265 (28): 17281–4. October 1990. doi:10.1016/S0021-9258(17)44900-3. PMID 2211625. 
  • "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connective Tissue Research 20 (1–4): 313–9. 1990. doi:10.3109/03008208909023902. PMID 2612162. 
  • "Novel regulators of bone formation: molecular clones and activities". Science 242 (4885): 1528–34. December 1988. doi:10.1126/science.3201241. PMID 3201241. Bibcode: 1988Sci...242.1528W. 
  • "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and Biophysical Research Communications 241 (3): 787–93. December 1997. doi:10.1006/bbrc.1997.7792. PMID 9434787. 
  • "Bone morphogenetic protein-3 is a negative regulator of bone density". Nature Genetics 27 (1): 84–8. January 2001. doi:10.1038/83810. PMID 11138004. 
  • "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology 16 (4): 1013–9. October 2001. PMID 11642720. 
  • "BMP signaling components are expressed in human fracture callus". Bone 33 (3): 362–71. September 2003. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778. 
  • "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy 11 (17): 1312–20. September 2004. doi:10.1038/sj.gt.3302298. PMID 15269709. 
  • "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". Journal of Orthopaedic Research 22 (6): 1188–92. November 2004. doi:10.1016/j.orthres.2004.02.013. PMID 15475196. 




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