Biology:Bone morphogenetic protein 10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[1][2]
BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.
BMP10 has also emerged as a novel atrial specific biomarker used in cardiovascular research, especially in the field of atrial fibrillation (AF). Latest research has revealed strong associations between plasma concentration of BMP10 and the risk for ischemic stroke in patients with atrial fibrillation as well as with the risk of AF recurrence after ablation for AF[3][4].
Further reading
- Davila S; Froeling FE; Tan A et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
- Hillier LW; Graves TA; Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- Mazerbourg S; Sangkuhl K; Luo CW et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Nakano N; Hori H; Abe M et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
- Marroni F; Pfeufer A; Aulchenko YS et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMID 20031603.
- Strausberg RL; Feingold EA; Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- David L; Mallet C; Mazerbourg S et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.
References
- ↑ "Entrez Gene: bone morphogenetic protein 10". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=27302.
- ↑ 2.0 2.1 "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. February 1999. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785.
- ↑ Hijazi, Ziad; Benz, Alexander P; Lindbäck, Johan; Alexander, John H; Connolly, Stuart J; Eikelboom, John W; Granger, Christopher B; Kastner, Peter et al. (2023-01-14). "Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation" (in en). European Heart Journal 44 (3): 208–218. doi:10.1093/eurheartj/ehac632. ISSN 0195-668X. PMID 36380569. PMC 9839419. https://academic.oup.com/eurheartj/article/44/3/208/6830621.
- ↑ Reyat, Jasmeet S.; Chua, Winnie; Cardoso, Victor R.; Witten, Anika; Kastner, Peter M.; Kabir, S. Nashitha; Sinner, Moritz F.; Wesselink, Robin et al. (2020-08-20). "Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation" (in en). JCI Insight 5 (16). doi:10.1172/jci.insight.139179. ISSN 2379-3708. PMID 32814717. PMC 7455124. https://insight.jci.org/articles/view/139179.
External links
- Human BMP10 genome location and BMP10 gene details page in the UCSC Genome Browser.
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