Biology:Bone morphogenetic protein 10
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Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[1][2]
BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.
BMP10 has also emerged as a novel atrial specific biomarker used in cardiovascular research, especially in the field of atrial fibrillation (AF). Latest research has revealed strong associations between plasma concentration of BMP10 and the risk for ischemic stroke in patients with atrial fibrillation as well as with the risk of AF recurrence after ablation for AF.[3][4]
Further reading
- "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity 11 (3): 232–238. April 2010. doi:10.1038/gene.2010.1. PMID 20237496.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–731. April 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". The Journal of Biological Chemistry 280 (37): 32122–32132. September 2005. doi:10.1074/jbc.M504629200. PMID 16049014.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–2127. October 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". American Journal of Physiology. Heart and Circulatory Physiology 293 (6). December 2007. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
- "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circulation. Cardiovascular Genetics 2 (4): 322–328. August 2009. doi:10.1161/CIRCGENETICS.108.833806. PMID 20031603.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–16903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood 109 (5): 1953–1961. March 2007. doi:10.1182/blood-2006-07-034124. PMID 17068149.
References
- ↑ "Entrez Gene: bone morphogenetic protein 10". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=27302.
- ↑ 2.0 2.1 "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mechanisms of Development 80 (2): 181–184. February 1999. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785.
- ↑ "Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation". European Heart Journal 44 (3): 208–218. January 2023. doi:10.1093/eurheartj/ehac632. PMID 36380569.
- ↑ "Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation". JCI Insight 5 (16). August 2020. doi:10.1172/jci.insight.139179. PMID 32814717.
External links
- Human BMP10 genome location and BMP10 gene details page in the UCSC Genome Browser.
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