Biology:ACVR1C
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[1]
ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[2]
Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1]
References
- ↑ 1.0 1.1 1.2 "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62. 2001. doi:10.1159/000059339. PMID 12063393.
- ↑ "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. July 2002. doi:10.1124/mol.62.1.65. PMID 12065756.
External links
- Human ACVR1C genome location and ACVR1C gene details page in the UCSC Genome Browser.
Further reading
- "ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease". Biochem. Biophys. Res. Commun. 382 (2): 309–14. 2009. doi:10.1016/j.bbrc.2009.03.014. PMID 19275893.
- "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15): 2010–22. 2001. doi:10.1101/gad.201801. PMID 11485994.
- "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity". Proc. Natl. Acad. Sci. U.S.A. 105 (20): 7252–6. 2008. doi:10.1073/pnas.0800272105. PMID 18480259. Bibcode: 2008PNAS..105.7252A.
- "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells". Biochem. Biophys. Res. Commun. 377 (3): 867–72. 2008. doi:10.1016/j.bbrc.2008.10.074. PMID 18951876.
- "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta". Biol. Reprod. 68 (5): 1719–26. 2003. doi:10.1095/biolreprod.102.013045. PMID 12606401.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7". J. Clin. Endocrinol. Metab. 89 (11): 5523–34. 2004. doi:10.1210/jc.2004-0893. PMID 15531507.
- "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7". Mol. Biol. Cell 19 (11): 4968–79. 2008. doi:10.1091/mbc.E08-03-0259. PMID 18784254.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells". J. Biol. Chem. 279 (27): 28458–65. 2004. doi:10.1074/jbc.M313277200. PMID 15107418. http://repository.ajou.ac.kr/bitstream/201003/3359/3/28458-28465.pdf.
- "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells". J. Biol. Chem. 279 (30): 31277–86. 2004. doi:10.1074/jbc.M400641200. PMID 15150278.
- "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines". Mol. Cancer Res. 4 (4): 235–46. 2006. doi:10.1158/1541-7786.MCR-05-0174. PMID 16603637.
- "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1–2): 59–65. 2004. doi:10.1016/j.mce.2004.03.009. PMID 15196700.
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