Biology:Zinc finger FYVE domain-containing protein 9
From HandWiki
Short description: Protein found in humans
 Generic protein structure example |
Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[1] SARA contains a double zinc finger (FYVE domain).
SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[2] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.
References
- ↑ "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell 95 (6): 779–791. December 1998. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696.
- ↑ "Cytoplasmic PML function in TGF-beta signalling". Nature 431 (7005): 205–211. September 2004. doi:10.1038/nature02783. PMID 15356634. Bibcode: 2004Natur.431..205L.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Zinc finger FYVE domain-containing protein 9
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