Biology:ACVR2B

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.[1][2][3] ACVR2B is an activin type 2 receptor.

Function

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.[3]

Interactions

ACVR2B has been shown to interact with ACVR1B[4][5] and SYNJ2BP.[6]

References

  1. "Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor". Blood 83 (8): 2163–70. May 1994. doi:10.1182/blood.V83.8.2163.2163. PMID 8161782. 
  2. "Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene". J. Hum. Genet. 43 (2): 132–4. July 1998. doi:10.1007/s100380050054. PMID 9621519. 
  3. Jump up to: 3.0 3.1 "Entrez Gene: ACVR2B activin A receptor, type IIB". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93. 
  4. "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. March 1996. doi:10.1128/mcb.16.3.1066. PMID 8622651. 
  5. "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. May 1996. doi:10.1006/excr.1996.0142. PMID 8612709. 
  6. "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. May 2002. doi:10.1074/jbc.M112472200. PMID 11882656. 

External links

Further reading