Biology:HTR3B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.

Further reading

• "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–957. 2009. doi:10.1038/ejhg.2008.264. PMID 19156168. 
• "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene". Pharmacogenet. Genomics 18 (3): 219–230. 2008. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944. 
• "Genetic susceptibility to heroin addiction; a candidate-gene association study". Genes, Brain and Behavior 7 (7): 720–729. 2008. doi:10.1111/j.1601-183X.2008.00410.x. PMID 18518925. 
• "Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients". Neuropsychobiology 53 (4): 186–195. 2006. doi:10.1159/000094727. PMID 16874005. 
• "The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor". J. Biol. Chem. 283 (11): 6826–6831. 2008. doi:10.1074/jbc.M707571200. PMID 18187416. 
• "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722–727. 2008. doi:10.1073/pnas.0708454105. PMID 18184810. Bibcode: 2008PNAS..105..722K. 
• "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population". Nagoya Journal of Medical Science 70 (1–2): 11–17. 2008. PMID 18807291. 
• "Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder". Mol. Psychiatry 15 (5): 473–500. 2008. doi:10.1038/mp.2008.116. PMID 18982004. 
• "Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors". Pharmacogenet. Genomics 18 (9): 793–802. 2008. doi:10.1097/FPC.0b013e3283050117. PMID 18698232. 
• "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population". Journal of Affective Disorders 117 (1–2): 87–97. 2009. doi:10.1016/j.jad.2008.12.021. PMID 19328558. 
• "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine". Gene 386 (1–2): 52–62. 2007. doi:10.1016/j.gene.2006.08.002. PMID 17010535. 
• "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis". Behavioral and Brain Functions 4: 48. 2008. doi:10.1186/1744-9081-4-48. PMID 18937842. 
• "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–1086. 2008. doi:10.1007/s00432-008-0387-1. PMID 18389280. 
• "Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea". Int. J. Neuropsychopharmacol. 11 (2): 261–267. 2008. doi:10.1017/S1461145707007985. PMID 17697394. 
• "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. 2009. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• "Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling". Pharmacogenet. Genomics 18 (12): 1027–1040. 2008. doi:10.1097/FPC.0b013e328310f950. PMID 19008750. 
• "Genetic evaluation of the serotonergic system in chronic fatigue syndrome". Psychoneuroendocrinology 33 (2): 188–197. 2008. doi:10.1016/j.psyneuen.2007.11.001. PMID 18079067. 
• "A common variant in DRD3 receptor is associated with autism spectrum disorder". Biol. Psychiatry 65 (7): 625–630. 2009. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789. 
• "HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power—an intermediate phenotype for alcoholism and co-morbid behaviors". Alcohol 43 (1): 73–84. 2009. doi:10.1016/j.alcohol.2008.09.005. PMID 19185213. 

External links

• HTR3B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)