Biology:Sulfur carrier protein ThiS adenylyltransferase
From HandWiki
| Sulfur carrier protein ThiS adenylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.73 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73, thiF (gene)) is an enzyme with systematic name ATP:(ThiS) adenylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- ATP + [ThiS] [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + adenylyl-[ThiS]
This enzyme binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine.
References
- ↑ "Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation". The Journal of Biological Chemistry 273 (26): 16555–60. June 1998. doi:10.1074/jbc.273.26.16555. PMID 9632726.
- ↑ "Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex". Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8513–8. July 2001. doi:10.1073/pnas.141226698. PMID 11438688.
- ↑ "Structural analysis of Escherichia coli ThiF". Journal of Molecular Biology 349 (4): 774–86. June 2005. doi:10.1016/j.jmb.2005.04.011. PMID 15896804.
- ↑ "Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis". Biochemistry 45 (1): 11–9. January 2006. doi:10.1021/bi051502y. PMID 16388576.
External links
- Sulfur+carrier+protein+ThiS+adenylyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
