Biology:Mannosyl-oligosaccharide 1,2-alpha-mannosidase
From HandWiki
| Mannosyl-oligosaccharide 1,2-α-mannosidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.2.1.113 | ||||||||
| CAS number | 9068-25-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Mannosyl-oligosaccharide 1,2-α-mannosidase (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-α-mannosidase, exo-α-1,2-mannanase, mannose-9 processing α-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-α-mannosyl-oligosaccharide α-D-mannohydrolase) is an enzyme with systematic name 2-α-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2] It catalyses the hydrolysis of the terminal (1→2)-linked α-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.
This enzyme is involved in the synthesis of glycoproteins.
Kifunensine is a potent inhibitor of mannosidase I.
References
- ↑ "Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides". The Journal of Biological Chemistry 254 (22): 11655–63. November 1979. doi:10.1016/s0021-9258(19)86534-1. PMID 500665.
- ↑ "α-D-Mannosidases of rat liver Golgi membranes: Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry 257 (7): 3660–8. April 1982. doi:10.1016/s0021-9258(18)34831-2. PMID 7061502.
External links
- Mannosyl-oligosaccharide+1,2-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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