Biology:CYP26A1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.[1][2][3]
Function
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.[3]
CYP26A1 is over-expressed in colorectal cancer cells compared to normal colonic epithelium but is of no independent prognostic value in patients with colorectal cancer.[4]
References
- ↑ "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". The Journal of Biological Chemistry 272 (30): 18538–41. July 1997. doi:10.1074/jbc.272.30.18538. PMID 9228017.
- ↑ "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics 48 (2): 270–2. March 1998. doi:10.1006/geno.1997.5157. PMID 9521883.
- ↑ 3.0 3.1 "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1592.
- ↑ "The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer". PLOS ONE 9 (3): e90776. 2014-03-07. doi:10.1371/journal.pone.0090776. PMID 24608339. Bibcode: 2014PLoSO...990776B.
External links
- Human CYP26A1 genome location and CYP26A1 gene details page in the UCSC Genome Browser.
Further reading
- "Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid". The Journal of Investigative Dermatology 106 (2): 316–20. February 1996. doi:10.1111/1523-1747.ep12342972. PMID 8601734.
- "CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family". The Journal of Biological Chemistry 272 (30): 18702–8. July 1997. doi:10.1074/jbc.272.30.18702. PMID 9228041.
- "Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells". Cell Growth & Differentiation 9 (8): 629–37. August 1998. PMID 9716180.
- "Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues". Biochemical and Biophysical Research Communications 252 (2): 487–91. November 1998. doi:10.1006/bbrc.1998.9659. PMID 9826557.
- "Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible". The British Journal of Dermatology 141 (3): 460–8. September 1999. doi:10.1046/j.1365-2133.1999.03039.x. PMID 10583049.
- "Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation". Biochemical Pharmacology 60 (4): 517–26. August 2000. doi:10.1016/S0006-2952(00)00356-7. PMID 10874126.
- "Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism". Molecular Endocrinology 14 (9): 1483–97. September 2000. doi:10.1210/mend.14.9.0518. PMID 10976925.
- "Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium". The Journal of Clinical Endocrinology and Metabolism 88 (5): 2157–63. May 2003. doi:10.1210/jc.2002-021844. PMID 12727970.
- "The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma". Metabolism 53 (8): 1007–12. August 2004. doi:10.1016/j.metabol.2003.12.015. PMID 15281009.
- "Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility". The Biochemical Journal 392 (Pt 1): 241–8. November 2005. doi:10.1042/BJ20050874. PMID 16053444.
- "Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells". Leukemia & Lymphoma 46 (10): 1497–506. October 2005. doi:10.1080/10428190500174737. PMID 16194896.
- "Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models". The Journal of Investigative Dermatology 126 (11): 2473–80. November 2006. doi:10.1038/sj.jid.5700432. PMID 16778795.
- "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida". Birth Defects Research. Part A, Clinical and Molecular Teratology 76 (6): 491–8. June 2006. doi:10.1002/bdra.20275. PMID 16933217.
- "Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding". Journal of Enzyme Inhibition and Medicinal Chemistry 21 (4): 361–9. August 2006. doi:10.1080/14756360600742014. PMID 17059167.
- "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity". Blood 109 (10): 4450–60. May 2007. doi:10.1182/blood-2006-10-051086. PMID 17218384.
- "The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system". Pharmacogenetics and Genomics 17 (3): 169–80. March 2007. doi:10.1097/FPC.0b013e32801152d6. PMID 17460545.
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