Biology:Triphosphate—protein phosphotransferase
| diphosphate-protein phosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.99.1 | ||||||||
| CAS number | 74092-32-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a triphosphate-protein phosphotransferase (EC 2.7.99.1) is an enzyme that catalyzes the chemical reaction
- triphosphate + [microsomal-membrane protein] [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + phospho-[microsomal-membrane protein]
Thus, the two substrates of this enzyme are triphosphate and microsomal-membrane protein, whereas its two products are diphosphate and phospho-[microsomal-membrane protein].
Classification
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups that are not covered by other phosphotransferase families.
Nomenclature
The systematic name of this enzyme class is triphosphate:[microsomal-membrane-protein] phosphotransferase. Other names in common use include diphosphate:microsomal-membrane-protein O-phosphotransferase, (erroneous), DiPPT (erroneous), pyrophosphate:protein phosphotransferase (erroneous), diphosphate-protein phosphotransferase (erroneous), diphosphate:[microsomal-membrane-protein] O-phosphotransferase, and (erroneous).
References
- "Pyrophosphate:protein phosphotransferase: a membrane-bound enzyme of endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 77 (4): 1927–31. 1980. doi:10.1073/pnas.77.4.1927. PMID 6246514.
- Tsutsui K (1986). "Tripolyphosphate is an alternative phosphodonor of the selective protein phosphorylation of liver microsomal membrane". J. Biol. Chem. 261 (6): 2645–53. doi:10.1016/S0021-9258(17)35836-2. PMID 3949741.
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