Biology:Inositol-polyphosphate multikinase
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Short description: Class of enzymes
| Inositol-polyphosphate multikinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.151 | ||||||||
| CAS number | 9077-69-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
- (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
- (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.
References
- ↑ "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology 9 (22): 1323–6. November 1999. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
- ↑ "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science 287 (5460): 2026–9. March 2000. doi:10.1126/science.287.5460.2026. PMID 10720331.
- ↑ "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". The Journal of Biological Chemistry 277 (45): 42711–8. November 2002. doi:10.1074/jbc.M209112200. PMID 12226109.
- ↑ "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry 280 (3): 1911–20. January 2005. doi:10.1074/jbc.M411528200. PMID 15531582.
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