Biology:RNF14
 Generic protein structure example |
E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.[1][2][3]
Function
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[3] Another function of RNF14 protein relates to its regulation of the inter-relationship between bioenergetic status and inflammation. It influences the expression of mitochondrial and immune-related genes in skeletal muscle including cytokines and interferon regulatory factors.[4]
Interactions
RNF14 has been shown to interact with the Androgen receptor.[1][5][6][7]
See also
References
- ↑ 1.0 1.1 "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem 274 (13): 8570–6. Apr 1999. doi:10.1074/jbc.274.13.8570. PMID 10085091.
- ↑ "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim Biophys Acta 1445 (2): 232–6. Jun 1999. doi:10.1016/s0167-4781(99)00045-7. PMID 10320776.
- ↑ 3.0 3.1 EntrezGene 9604
- ↑ "RNF14 is a regulator of mitochondrial and immune function in muscle". BMC Systems Biology 8: 10. January 2014. doi:10.1186/1752-0509-8-10. PMID 24472305.
- ↑ "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. Feb 2002. doi:10.1074/jbc.M108312200. PMID 11673464.
- ↑ "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. Mar 2002. doi:10.1074/jbc.M111975200. PMID 11779876.
- ↑ "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. Mar 2003. doi:10.1128/mcb.23.6.2135-2150.2003. PMID 12612084.
Further reading
- "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. 1999. doi:10.1038/4315. PMID 9853615.
- "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. 2001. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
- "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. 2002. doi:10.1074/jbc.M108312200. PMID 11673464.
- "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. 2002. doi:10.1074/jbc.M203313200. PMID 12163482.
- "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs". Mol. Cell. Biol. 23 (6): 2135–50. 2003. doi:10.1128/MCB.23.6.2135-2150.2003. PMID 12612084.
- "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines". Prostate 56 (3): 192–200. 2003. doi:10.1002/pros.10229. PMID 12772188.
- "Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells". Mol. Cell. Biol. 24 (5): 2202–13. 2004. doi:10.1128/MCB.24.5.2202-2213.2004. PMID 14966297.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. 2004. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661.
- "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. 2007. doi:10.1210/me.2006-0104. PMID 17082327.
- "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54". Endocrinology 148 (3): 1340–9. 2007. doi:10.1210/en.2006-0716. PMID 17110431.
- "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells". Carcinogenesis 28 (8): 1752–8. 2007. doi:10.1093/carcin/bgm120. PMID 17510080.
External links
- RNF14 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C127
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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