Biology:GABRG1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene. The protein encoded by this gene is a subunit of the GABAA receptor.

Variants of this gene may be associated with alcohol dependence.

Further reading

• "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815–823. 2002. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. 
• "An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.". Neuropathology 29 (3): 263–269. 2009. doi:10.1111/j.1440-1789.2008.00978.x. PMID 19019179. 
• "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry 15 (2): 146–153. 2010. doi:10.1038/mp.2008.66. PMID 19078961. 
• "Associations among GABRG1, level of response to alcohol, and drinking behaviors.". Alcohol. Clin. Exp. Res. 33 (8): 1382–1390. 2009. doi:10.1111/j.1530-0277.2009.00968.x. PMID 19426171. 
• "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–69. 2008. doi:10.1016/j.ygeno.2007.08.007. PMID 17976953. 
• "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. 2009. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. 1999. doi:10.1073/pnas.96.17.9891. PMID 10449790. Bibcode: 1999PNAS...96.9891B. 
• "Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation". Arch. Gen. Psychiatry 66 (9): 947–956. 2009. doi:10.1001/archgenpsychiatry.2009.80. PMID 19736351. PMC 2958844. http://www.hal.inserm.fr/inserm-00417413/document. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism". Am. J. Hum. Genet. 77 (3): 377–388. 2005. doi:10.1086/433195. PMID 16080114. 
• "Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene". Neuropsychopharmacology 33 (4): 837–848. 2008. doi:10.1038/sj.npp.1301456. PMID 17507911. 
• "GABRG1 and GABRA2 as independent predictors for alcoholism in two populations". Neuropsychopharmacology 34 (5): 1245–1254. 2009. doi:10.1038/npp.2008.171. PMID 18818659. 
• "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–5861. 1992. doi:10.1073/pnas.89.13.5857. PMID 1321425. Bibcode: 1992PNAS...89.5857W. 

External links

• GABRG1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)