Biology:1-phosphatidylinositol 4-kinase
| 1-phosphatidylinositol 4-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Phosphatidylinositol 4-kinase homo16mer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 2.7.1.67 | ||||||||
| CAS number | 37205-54-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction
- ATP + 1-phosphatidyl-1D-myo-inositol [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
As of late 2007, the structure has only been solved for this enzyme. Part of the enzyme was crystallized with its activating partner frequenin.[1]
References
- ↑ Strahl T; Huttner IG; Lusin JD et al. (October 2007). "Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)". J. Biol. Chem. 282 (42): 30949–59. doi:10.1074/jbc.M705499200. PMID 17720810.
- "Biosynthesis of diphosphoinositide in brain". J. Biol. Chem. 240 (10): 3771–80. 1965. PMID 4284712.
- "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328–37. 1966. doi:10.1042/bj1010328. PMID 4290722.
- "Purification and characterization of a phosphatidylinositol kinase from A431 cells". Biochemistry 27 (17): 6504–11. 1988. doi:10.1021/bi00417a046. PMID 2851325.
- "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature 332 (6165): 644–6. 1988. doi:10.1038/332644a0. PMID 2833705. Bibcode: 1988Natur.332..644W.
- Barylko B; Gerber, SH; Binns, DD; Grichine, N; Khvotchev, M; Südhof, TC; Albanesi, JP (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087.
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