Biology:Nicotinate-nucleotide adenylyltransferase
| nicotinate-nucleotide adenylyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.7.18 | ||||||||
| CAS number | 9026-98-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) is an enzyme that catalyzes the chemical reaction
- ATP + nicotinate ribonucleotide [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + deamido-NAD+
Thus, the two substrates of this enzyme are ATP and nicotinate ribonucleotide, whereas its two products are diphosphate and deamido-NAD+.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinate-ribonucleotide adenylyltransferase. Other names in common use include deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, and nicotinic acid mononucleotide adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1K4K, 1K4M, 1KAM, 1KAQ, 1YUL, 1YUM, 1YUN, 2H29, and 2H2A.
References
- "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". The Journal of Biological Chemistry 236: 1494–7. May 1961. PMID 13717628.
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