Biology:Glycoside hydrolase family 44
| Glycoside hydrolase family 44 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_44 | ||||||||
| Pfam | PF12891 | ||||||||
| Pfam clan | CL0058 | ||||||||
| CAZy | GH44 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 44 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 44 CAZY GH_44, formerly known as cellulase family J, includes enzymes with endoglucanase EC 3.2.1.4 and xyloglucanase EC 3.2.1.151 activities. The overall structure of enzymes in this family consists of a TIM-like barrel domain, a beta-sandwich domain and an active site with two glutamic acid residues, all of which are conserved between the endoglucanases and xyloglucanases in the family, with only minor differences.[8][9]
References
- ↑ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. Bibcode: 1995PNAS...92.7090H.
- ↑ "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 (Pt 2): 695–6. June 1996. doi:10.1042/bj3160695. PMID 8687420.
- ↑ "Home" (in en). http://www.cazy.org/.
- ↑ "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490-5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786.
- ↑ "Glycoside Hydrolase Family 44" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_44.
- ↑ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.
- ↑ "Crystal structure of Cel44A, a glycoside hydrolase family 44 endoglucanase from Clostridium thermocellum". The Journal of Biological Chemistry 282 (49): 35703–11. December 2007. doi:10.1074/jbc.M706835200. PMID 17905739.
- ↑ "Structure and activity of Paenibacillus polymyxa xyloglucanase from glycoside hydrolase family 44". The Journal of Biological Chemistry 286 (39): 33890–900. September 2011. doi:10.1074/jbc.M111.262345. PMID 21795708.
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