Biology:1-phosphatidylinositol-4-phosphate 5-kinase
| 1-phosphatidylinositol-4-phosphate 5-kinase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.1.68 | ||||||||
| CAS number | 104645-76-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction
- ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of the actin cytoskeleton.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BO1 and 2GK9.
References
- "The diphosphoinositide kinase of rat brain". Biochem. J. 106 (4): 791–801. 1968. doi:10.1042/bj1060791. PMID 4295336.
- "The biosynthesis of triphosphoinositide by rat brain in vitro". Biochem. Biophys. Res. Commun. 22 (4): 370–375. 1966. doi:10.1016/0006-291X(66)90655-3.
- "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature 390 (6656): 192–6. 1997. doi:10.1038/36621. PMID 9367159. Bibcode: 1997Natur.390..192R.
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