Biology:Glycoside hydrolase family 30
| O-Glycosyl hydrolase family 30 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of a xylanase from glycoside hydrolase family 5.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Glyco_hydro_30 | ||||||||
| Pfam | PF02055 | ||||||||
| Pfam clan | CL0058 | ||||||||
| InterPro | IPR001139 | ||||||||
| SCOP2 | 1nof / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 117 | ||||||||
| OPM protein | 1ogs | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 30 is a family of glycoside hydrolases.[citation needed]
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy web site,[5][6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[7][8]
Glycoside hydrolase family 30 CAZY GH_30 includes the mammalian glucosylceramidases. Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase), cleaves the glucosidic bonds of glucosylceramide and synthetic beta-glucosides.[9] Any one of over 50 different mutations in the gene of glucocerebrosidase have been found to affect activity of this hydrolase, producing variants of Gaucher disease, the most prevalent lysosomal storage disease.[9][10]
References
- ↑ "First crystallographic structure of a xylanase from glycoside hydrolase family 5: implications for catalysis". Biochemistry 42 (28): 8411–22. July 2003. doi:10.1021/bi034144c. PMID 12859186.
- ↑ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. Bibcode: 1995PNAS...92.7090H.
- ↑ "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 (Pt 2): 695–6. June 1996. doi:10.1042/bj3160695. PMID 8687420.
- ↑ "Home" (in en). http://www.cazy.org/.
- ↑ "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490-5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786.
- ↑ "Glycoside Hydrolase Family 30" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_30.
- ↑ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.
- ↑ 9.0 9.1 "Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site". Proceedings of the National Academy of Sciences of the United States of America 83 (6): 1660–4. March 1986. doi:10.1073/pnas.83.6.1660. PMID 3456607. Bibcode: 1986PNAS...83.1660D.
- ↑ "Differences in origin of the 1448C mutation in patients with Gaucher disease". Acta Paediatrica Japonica 39 (4): 451–3. August 1997. doi:10.1111/j.1442-200x.1997.tb03616.x. PMID 9316290.
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