Biology:CYP2W1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.
References
- ↑ "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. October 2004. doi:10.1101/gr.2596504. PMID 15489334.
- ↑ Template:NCBI RefSeq
External links
- Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. 2008. doi:10.1124/dmd.107.019141. PMID 17998294.
- "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. 2006. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
- "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. 2006. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
- "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics 8 (10): 1315–25. 2007. doi:10.2217/14622416.8.10.1315. PMID 17979506.
- "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. 2004. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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