Biology:GLRB
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[1][2][3]
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][3]
See also
References
- ↑ "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics 50 (3): 341–5. Oct 1998. doi:10.1006/geno.1998.5324. PMID 9676428.
- ↑ "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res 35 (1–2): 211–9. Oct 1996. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
- ↑ 3.0 3.1 "Entrez Gene: GLRB glycine receptor, beta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2743.
Further reading
- "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron 15 (3): 563–72. 1995. doi:10.1016/0896-6273(95)90145-0. PMID 7546736.
- "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron 82 (3): 254–60. 1999. doi:10.1159/000045410. PMID 10395998.
- "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. 2002. doi:10.1093/hmg/11.7.853. PMID 11929858.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. 2004. doi:10.1074/jbc.M307684200. PMID 14563849.
- "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels 9 (6): 353–61. 2004. doi:10.3109/714041016. PMID 14698963.
- "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. 2004. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304. PMC 6729214. http://discovery.ucl.ac.uk/9558/1/9558.pdf.
- "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron 45 (5): 727–39. 2005. doi:10.1016/j.neuron.2005.01.028. PMID 15748848.
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External links
- GLRB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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