Biology:CHRNB2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.

See also

• Nicotinic acetylcholine receptor

Further reading

• "[Molecular and genetic basis of idiopathic nocturnal frontal lobe epilepsy]". Neurol. Neurochir. Pol. 36 (3): 513–25. 2002. PMID 12185808. 
• "Binding of HIV-1 gp120 to the nicotinic receptor". FEBS Lett. 311 (2): 115–8. 1992. doi:10.1016/0014-5793(92)81380-5. PMID 1397297. 
• "Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene". Nucleic Acids Res. 18 (14): 4272. 1990. doi:10.1093/nar/18.14.4272. PMID 2377478. 
• "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. 1997. doi:10.1007/BF02736842. PMID 8906617. 
• "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. 1997. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
• "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)". Hum. Genet. 103 (6): 645–53. 1999. doi:10.1007/s004390050885. PMID 9921897. 
• "Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes". Mamm. Genome 10 (9): 900–5. 1999. doi:10.1007/s003359901111. PMID 10441742. https://zenodo.org/record/1232695. 
• Steinlein OK (2000). "Neuronal nicotinic receptors in human epilepsy". Eur. J. Pharmacol. 393 (1–3): 243–7. doi:10.1016/S0014-2999(00)00065-0. PMID 10771020. 
• "The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy". Nat. Genet. 26 (3): 275–6. 2000. doi:10.1038/81566. PMID 11062464. 
• "CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy". Am. J. Hum. Genet. 68 (1): 225–31. 2001. doi:10.1086/316946. PMID 11104662. 
• "Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR". Acta Neurol. Scand. Suppl. 176: 68–73. 2001. doi:10.1034/j.1600-0404.2000.00310.x. PMID 11261808. 
• "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease". Protein Expression in Down Syndrome Brain. 2002. 211–22. doi:10.1007/978-3-7091-6262-0_17. ISBN 978-3-211-83704-7. 
• "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)". Nicotine Tob. Res. 4 (1): 115–25. 2002. doi:10.1080/14622200110098419. PMID 11906688. 
• "Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy". Epilepsia 43 (4): 362–4. 2002. doi:10.1046/j.1528-1157.2002.39001.x. PMID 11952766. 
• "A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors". J. Clin. Invest. 110 (4): 527–36. 2002. doi:10.1172/JCI14676. PMID 12189247. 
• "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor". J. Biol. Chem. 277 (44): 41872–8. 2003. doi:10.1074/jbc.M206857200. PMID 12202488. 
• "Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease". J. Alzheimers Dis. 4 (2): 71–6. 2002. doi:10.3233/JAD-2002-4201. PMID 12214130. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 

External links

• CHRNB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNB2 genome location and CHRNB2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P17787 (Neuronal acetylcholine receptor subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.