Biology:Α-L-fucosidase

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α-L-Fucosidase
PDB 1hl8 EBI.jpg
crystal structure of Thermotoga maritima α-fucosidase
Identifiers
Symbolα
PfamPF01120
Pfam clanCL0058
InterProIPR000933
PROSITEPDOC00324
SCOP21hl9 / SCOPe / SUPFAM
CAZyGH29
α-L-fucosidase
Identifiers
EC number3.2.1.51
CAS number9037-65-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme α-L-fucosidase (EC 3.2.1.51) catalyzes the following chemical reaction: an α-L-fucoside + H2O [math]\displaystyle{ \rightleftharpoons }[/math] L-fucose + an alcohol

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase. It participates in N-glycan degradation and glycan structure degradation.

Deficiency of this enzyme is called Fucosidosis.

In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

Human medical studies

It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

See also

References

  1. Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E. Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients. Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x.

Further reading

External links