Biology:ATP adenylyltransferase

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ATP adenylyltransferase
Identifiers
EC number2.7.7.53
CAS number96697-71-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an ATP adenylyltransferase (EC 2.7.7.53) is an enzyme that catalyzes the chemical reaction

ADP + ATP [math]\displaystyle{ \rightleftharpoons }[/math] phosphate + P1,P4-bis(5'-adenosyl) tetraphosphate

Thus, the two substrates of this enzyme are ADP and ATP, whereas its two products are phosphate and P1,P4-bis(5'-adenosyl) tetraphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ADP:ATP adenylyltransferase. Other names in common use include bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming), diadenosinetetraphosphate alphabeta-phosphorylase, adenine triphosphate adenylyltransferase, diadenosine 5',5'"-P1,P4-tetraphosphate alphabeta-phosphorylase, (ADP-forming), and dinucleoside oligophosphate alphabeta-phosphorylase. This enzyme participates in purine metabolism.

References

  • "Phosphorolytic cleavage of diadenosine 5',5-P1,P4-tetraphosphate Properties of homogeneous diadenosine 5',5-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae". J. Biol. Chem. 260 (6): 3542–7. 1985. PMID 2982863.