Biology:Beta-mannosidase
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
| β-Mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.25 | ||||||||
| CAS number | 9025-43-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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β-Mannosidase (EC 3.2.1.25}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: mannosidase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4126.
- ↑ "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. February 1995. doi:10.1074/jbc.270.8.3841. PMID 7876128.
- ↑ Adams, M.; Richtmyer, N.K.; Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.
- ↑ Bartholomew, B.A.; Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.
- ↑ Deuel, H.; Lewuenberger, R.; Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta 33 (4): 942–946. doi:10.1002/hlca.19500330424.
- ↑ Hylin, J.W.; Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. doi:10.1016/S0021-9258(18)91377-3. PMID 14165949.
Further reading
- "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. 1996. doi:10.1097/00042560-199607000-00001. PMID 8673525.
- "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. 2010. doi:10.1093/hmg/ddq112. PMID 20332099.
- "Human β-mannosidase deficiency associated with peripheral neuropathy". Ann. Neurol. 35 (1): 116–9. 1994. doi:10.1002/ana.410350119. PMID 8285582.
- "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. 1996. doi:10.1128/jvi.70.11.7462-7470.1996. PMID 8892864.
- "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry 32 (41): 11087–99. 1993. doi:10.1021/bi00092a019. PMID 8218172.
- "A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant". BMC Med. Genet. 10: 84. 2009. doi:10.1186/1471-2350-10-84. PMID 19728872.
- "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med 66 (12): 848–53. 2009. doi:10.1136/oem.2008.044024. PMID 19773279.
- "Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis". Hum. Mol. Genet. 7 (1): 75–83. 1998. doi:10.1093/hmg/7.1.75. PMID 9384606.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. 1997. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416.
- "MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations". Acta Oncol 47 (3): 372–8. 2008. doi:10.1080/02841860701644052. PMID 17899454.
- "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses 3 (3): 265–82. 1987. doi:10.1089/aid.1987.3.265. PMID 2829950.
- "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. 1988. doi:10.1073/pnas.85.23.9248. PMID 3264072. Bibcode: 1988PNAS...85.9248M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. 1993. doi:10.1128/jvi.67.1.150-160.1993. PMID 8093218.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie 83 (8): 783–90. 2001. doi:10.1016/S0300-9084(01)01314-1. PMID 11530211.
- "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. 1986. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
- "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–60. 2003. doi:10.1099/vir.0.18734-0. PMID 12560567.
External links
- Human MANBA genome location and MANBA gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q8K2I4 (Mouse Beta-mannosidase) at the PDBe-KB.
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